Table 2 Impact of current AECB episode on daily life activities and sleep disturbance (efficacy population)
Parameter | Days with impact on daily life activities | Nights with sleep disturbance | ||||
|---|---|---|---|---|---|---|
(N = 2292) | (N = 1740) | |||||
n (%) | Mean | SD | n (%) | Mean | SD | |
Gender | ||||||
Male | 1308 (57.1) | 6.6 | 5.3 | 971 (55.8) | 4.1 | 3.8 |
Female | 984 (42.9) | 6.6 | 5.8 | 769 (44.2) | 4.1 | 3.6 |
Missing | 0 (0) | - | - | 0 (0) | - | - |
Age group (years) | ||||||
≥ 35 to < 50 | 615 (26.8) | 6.4 | 5.2 | 406 (23.3) | 3.7 | 2.7 |
≥ 50 to < 65 | 922 (40.2) | 6.7 | 5.9 | 712 (40.9) | 4.0 | 4.1 |
≥ 65 to < 80 | 680 (29.7) | 6.7 | 5.3 | 557 (32.0) | 4.5 | 3.8 |
≥ 80 | 71 (3.1) | 5.8 | 3.9 | 63 (3.6) | 4.3 | 3.0 |
Missing | 4 (0.2) | 11.8 | 5.2 | 2 (0.1) | 4.0 | 1.4 |
Smoking status | ||||||
Never | 1027 (44.8) | 6.7 | 5.6 | 786 (45.2) | 4.0 | 3.7 |
Past or current smoker | 1255 (54.8) | 6.5 | 5.4 | 945 (54.3) | 4.2 | 3.7 |
Missing | 10 (0.4) | 8.7 | 5.3 | 9 (0.5) | 3.6 | 2.1 |
Concomitant diseases of special interest | ||||||
COPD | 1549 (67.6) | 6.6 | 5.6 | 1216 (69.9) | 4.3 | 3.9 |
Asthma | 389 (17.0) | 7.5 | 6.8 | 331 (19.0) | 4.4 | 3.5 |
Emphysema | 568 (24.8) | 7.7 | 6.4 | 461 (26.5) | 4.5 | 3.7 |
Bronchiectasis | 151 (6.6) | 7.3 | 6.9 | 128 (7.4) | 4.6 | 4.7 |
Cor pulmonale | 251 (11.0) | 8.1 | 6.4 | 222 (12.8) | 5.1 | 4.2 |
Cardiomyopathy | 146 (6.4) | 7.9 | 7.4 | 122 (7.0) | 5.4 | 5.0 |
Cardiac ischemia | 544 (23.7) | 7.2 | 6.3 | 429 (24.7) | 4.2 | 3.5 |
Heart insufficiency | 135 (5.9) | 10.9 | 10.1 | 126 (7.2) | 6.4 | 6.3 |
Cardiac arrhythmia | 145 (6.3) | 7.7 | 5.1 | 131 (7.5) | 4.9 | 4.0 |
Chronic alcoholism | 39 (1.7) | 6.0 | 6.8 | 24 (1.4) | 5.3 | 5.5 |
Diabetes | 238 (10.4) | 6.3 | 5.3 | 196 (11.3) | 4.1 | 3.2 |
No diseases of special interest | 324 (14.1) | 5.8 | 4.1 | 203 (11.7) | 3.0 | 2.8 |
Anthonisen grade | ||||||
Type I | 1014 (44.2) | 7.1 | 5.1 | 793 (45.6) | 4.5 | 3.8 |
Type II | 913 (39.8) | 6.5 | 5.9 | 666 (38.3) | 3.8 | 3.6 |
Type III | 353 (15.4) | 5.6 | 5.6 | 274 (15.7) | 3.6 | 3.3 |
Missing | 12 (0.5) | 7.4 | 6.2 | 7 (0.4) | 7.3 | 7.5 |
Number of severe symptoms per patient at start of therapy | ||||||
1 | 446 (19.5) | 6.0 | 5.2 | 295 (17.0) | 3.5 | 3.5 |
2 | 596 (26.0) | 6.0 | 5.0 | 417 (24.0) | 3.5 | 3.3 |
3 | 377 (16.4) | 6.3 | 5.0 | 279 (16.0) | 4.1 | 3.1 |
4 | 241 (10.5) | 6.8 | 5.4 | 193 (11.1) | 4.4 | 3.9 |
5 | 163 (7.1) | 7.7 | 4.9 | 142 (8.2) | 4.9 | 3.4 |
6 | 142 (6.2) | 10.2 | 7.9 | 141 (8.1) | 5.8 | 3.7 |
7 | 66 (2.9) | 9.6 | 7.5 | 66 (3.8) | 6.2 | 5.8 |
8 | 16 (0.7) | 10.4 | 9.6 | 15 (0.9) | 8.1 | 8.6 |
None | 245 (10.7) | 5.6 | 4.6 | 192 (11.0) | 3.2 | 3.1 |