Unadjusted | Adjusted* | ||||||
---|---|---|---|---|---|---|---|
OR | 95% CI | p | OR | 95% CI | p | ||
Comorbidity | |||||||
Ischemic heart disease | 1.42 | (1.38, 1.46) | <0.001 | 1.31 | (1.27, 1.35) | <0.001 | |
Osteoporosis | 1.57 | (1.52, 1.61) | <0.001 | 1.46 | (1.42, 1.51) | <0.001 | |
Depressive disorder | 2.02 | (1.95, 2.10) | <0.001 | 1.87 | (1.79, 1.94) | <0.001 | |
Arthritis | 1.60 | (1.55, 1.64) | <0.001 | 1.55 | (1.51, 1.60) | <0.001 | |
Diabetes mellitus | 1.23 | (1.20, 1.27) | <0.001 | 1.14 | (1.11, 1.17) | <0.001 | |
Congestive heart failure | 1.13 | (1.08, 1.17) | <0.001 | 1.04 | (0.99, 1.08) | 0.078 | |
Hypertension | 1.15 | (1.13, 1.18) | <0.001 | 1.11 | (1.09, 1.14) | <0.001 | |
Anemia | 1.53 | (1.45, 1.61) | <0.001 | 1.39 | (1.32, 1.46) | <0.001 | |
Metabolic syndrome | 1.56 | (1.52, 1.61) | <0.001 | 1.45 | (1.41, 1.49) | <0.001 | |
Barrett’s esophagus | 14.46 | (5.01, 41.73) | <0.001 | 15.10 | (5.21, 43.79) | <0.001 | |
Gastric ulcer | 2.58 | (2.52, 2.65) | <0.001 | 2.45 | (2.38, 2.51) | <0.001 | |
Duodenal ulcer | 2.72 | (2.57, 2.88) | <0.001 | 2.65 | (2.51, 2.81) | <0.001 | |
Peptic ulcer | 1.82 | (1.77, 1.88) | <0.001 | 1.74 | (1.69, 1.79) | <0.001 | |
Gastroduodenitis | 2.96 | (2.85, 3.07) | <0.001 | 2.82 | (2.71, 2.92) | <0.001 | |
Drug | |||||||
ICS | 1.33 | (1.29, 1.38) | <0.001 | 1.13 | (1.09, 1.17) | <0.001 | |
ICS/LABA | 1.14 | (1.11, 1.16) | <0.001 | 1.05 | (1.02, 1.08) | <0.001 | |
LAMA | 1.06 | (1.03, 1.09) | <0.001 | 0.99 | (0.96, 1.02) | 0.567 | |
LABA | 1.12 | (0.75, 1.67) | 0.568 | 1.11 | (0.74, 1.65) | 0.624 | |
LTRA | 1.35 | (1.31, 1.39) | <0.001 | 1.27 | (1.23, 1.30) | <0.001 | |
OCS | 1.45 | (1.42, 1.49) | <0.001 | 1.37 | (1.34, 1.40) | <0.001 | |
SAMA | 1.20 | (1.17, 1.24) | <0.001 | 0.96 | (0.93, 0.99) | 0.015 | |
SABA | 1.19 | (1.16, 1.22) | <0.001 | 1.02 | (0.99, 1.04) | 0.237 | |
SABA/SAMA | 1.02 | (0.95, 1.10) | 0.627 | 0.97 | (0.90, 1.04) | 0.339 | |
Oral beta-2 agonists | 1.16 | (1.13, 1.19) | <0.001 | 1.11 | (1.09, 1.14) | <0.001 | |
Theophylline | 1.15 | (1.11, 1.19) | <0.001 | 1.10 | (1.07, 1.14) | <0.001 |