Effect of GSTM2-5polymorphisms in relation to tobacco smoke exposures on lung function growth: a birth cohort study

Table 5 Adjusted means of FEV ₁ and FVC in mL by diplotype and CpG methylation percentile

				Methylation percentile for cg06970744†,§
Outcome	Gene	n	Diplotype*	25th percentile	50th percentile	75th percentile	p_interaction‡
FEV₁	GSTM5	203	AA_AG	3427.61	3457.13	3497.90	0.02
			AA_CA	3584.62	3549.29	3500.49
			AG_CA	3584.46	3536.99	3471.43
			CA_CA	3206.02	3349.07	3546.64
			Minor diplotypes	3527.80	3721.73	3989.59
			AA_AA	3499.59	3503.89	3509.84
FVC	GSTM5	203	AA_AG	4020.50	4036.67	4059.00	0.02
			AA_CA	4091.55	4067.27	4033.75
			AG_CA	3864.29	3951.14	4071.09
			CA_CA	3850.02	4016.73	4246.98
			Minor diplotypes	4004.33	4292.32	4690.09
			AA_AA	3975.89	3981.64	3989.57

*Comprised of SNPs as described in the Results section, means for minor diplotypes grouping in GSTM2 were not estimable; †Models adjusted for rs366631, in utero smoke exposure, current smoking, secondhand smoke exposure, body mass index (BMI) and height; ‡ Global F-test p-value: significance of interaction; § Name of methylation site is derived from Illumina ID.

ISSN: 1471-2466