Table 3 Treatment differences between ex-, current- and never- smokers after 2-week ICS treatment
From: Inflammation and corticosteroid responsiveness in ex-, current- and never-smoking asthmatics
Ex-smokers (n=19) | p-value | Current-smokers (n=19) | p-value | Never-smokers (n=38) | p-value | |
|---|---|---|---|---|---|---|
Age (years) | 38 (28, 44) | 27 (25, 42) | 25 (25, 36) | |||
Gender (male/female) | 9 / 10 | 4 / 15 | 12 / 26 | |||
Treatment (FP500/FP2000) | 11 / 8 | 6 / 13 | 20 / 18 | |||
ΔFEV1 (L) | 0.14 (-0.07, 0.31) | 0.051 | 0.08* (-0.05, 0.32) | 0.113 | 0.30 (0.18, 0.77) | <0.001 |
ΔFEV1 (%predicted) | 4.1# (-2.1, 9.2) | 0.073 | 2.4* (-4.7, 8.7) | 0.172 | 8.1 (4.6, 20.4) | <0.001 |
ΔReversibility (%predicted) | -4.8 (-8.1, -0.3) | 0.022 | -4.3 (-7.9, 2.3) | 0.025 | -6.8 (-9.7, -2.9) | <0.001 |
ΔPC20 methacholine (doubling concentrations) | 1.3# (0.4, 2.0) | 0.001 | 1.4 (0.3, 2.4) | 0.001 | 2.3 (1.1, 3.2) | <0.001 |
ΔPC20 AMP (doubling concentrations) | 3.1 (0.4, 5.7) | 0.001 | 0.9# (0.1, 5.6) | 0.007 | 5.1 (2.2, 6.4) | <0.001 |
ΔSputum eosinophils (%) | -1.4 (-5.7, -0.7) | <0.001 | -1.0‡ (-4.5, 0.0) | 0.004 | -6.3 (-14.5, -2.2) | <0.001 |
ΔBlood eosinophils (109/L) | -0.05 (-0.16, 0.02) | 0.018 | -0.02 (-0.15, 0.03) | 0.060 | -0.16 (-0.28, -0.01) | 0.002 |
ΔSputum ECP (μg/L) | -12 (-82, -1) | 0.022 | -10*§ (-48, 9) | 0.219 | -31 (-135, -1) | <0.001 |
ΔSerum ECP (μg/L) | -1.3 (-4.5, 2.1) | 0.564 | -2.4# (-15.0, -4.2) | 0.303 | -6.9 (-14.6, -1.0) | <0.001 |
ΔSputum neutrophils (109/L) | -3.3 (-17.4, 7.8) | 0.270 | -2.7§ (-15.0, 4.2) | 0.496 | 0.5 (-7.8, 6.3) | 0.382 |
ΔBlood neutrophils (109/L) | 0.31 (-0.57, 0.78) | 0.625 | 0.27§ (-0.47, 0.97) | 0.902 | 0.22 (-0.26, 0.79) | 0.563 |
ΔExhaled NO (ppb) | -3.3 (-6.8, 0.00) | 0.039 | -3.6 (-6.8, 3.1) | 0.248 | -5.1 (-8.4, -2.1) | <0.001 |