Course of FEV1 (%pred) and the inflammatory marker IgG (g/l) of CF patients positive for Trichosporon . Mean FEV1 and IgG values for 7 Trichosporon positive patients with sufficiently long follow-up periods at 7 time intervals: 1 and 2 years before first Trichosporon detection, at first detection, 1, 2 and 3 years after first detection and at the end of the observation period. The mean number of data points per year was 4 (range 2–7). Each symbol/line represents one patient. The solid lines represent the patients with a decline in FEV1. The grey line represents the patient with only a single Trichosporon positive specimen.