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Table 1 Characterization and follow-up of CF patients positive for Trichosporon

From: The basidiomycetous yeast Trichosporon may cause severe lung exacerbation in cystic fibrosis patients – clinical analysis of Trichosporonpositive patients in a Munich cohort

Patient number

1

2

3

4

5

6

7

8

Sex

F

M

F

M

F

F

M

F

Mutation

dF508/ dF508

dF508/ dF508

dF508/ Nk

dF508/ R553X

dF508/ S466X

dF508/ Nk

dF508/ Nk

dF508/ R553X

Age at first detection (y)

41.1

33.0

10.0

11.0

21.7

8.0

22.3

27.6

Age at last detection (y)

43.0

36.9

17.8

11.0

28.4

8.6

29.2

28.4

Follow up (y) *

3.1

5.9

7.8

2.4

6.7

5.3

6.9

0.8

Trichosporon species

Nk

Asahii

Inkin

Nk

Mycotoxinivorans

Nk

Nk

Nk

Other isolated organisms from sputum (at first detection)

Ps ae (chron), Ps ae muc

E col, Prot mirab

None

Norcard farc, Inqu lin, Burc cep, Asp fum, Penicill sp

Ps ae (chron), Cand alb

Acinet baum, fungi (not spec), Ps ae (chron)

Ps ae (chron), Ps ae muc, Cand alb

Ps ae muc (chron), Cand alb

Other isolated organisms from sputum (throughout observation period)

Pseudoall boyd (rep), Cand glab (rep), Cand alb (rep), Cand paraps (rep), Enteroc spp. (rep), Asp fum (rep)

Prot mirab (rep), Asp fum (rep)

Asp fum (rep), Sten mal (rep), Cand alb (rep), Sa (rep)

Inqu lin (rep), Burc cep (rep), Penicill sp (rep), Acinet fum (rep), Ps put (once)

E coli (rep), Sten malt (rep), Asp flav (rep)

Acinet baum (rep), Pet sord (rep)

Asp fum (rep), Prot mirab (rep), Sa (rep), Enteroc spp (rep), Cand alb (rep)

Cand paraps (rep)

Antibiotic regimen prior to first detection (agent; regimen)

        

Oral

Cip (cont)

Cefur (cont), Cip (2 w on/off)

Cep (cont), Cip (2 w on/off)

Ceph (cont), Cip (2 w on/off)

Ceph (cont)

Ceph (cont), cip (2 w on/off)

Ceph (cont)

Cot (cont)

Inhaled

Tob/col (2 w on/off)

None

Col (2 w on/off)

Tob/col (2 w on/off)

Gern (2 w on/off)

None

Gern (2 w on/off)

Gern/col (2 w on/off)

iv (courses/y)

2

2

1

1

2

1

1

2

Diabetes mellitus (at first detection)

Yes

Yes

no

No

No

No

No

No

ABPA (years prior to first detection)

5y, 2y

3y

no

3y, 1y

No

1 y after first detection

No

At first detection

Nebulized/inhaled steroids prior to first detection (duration)

Yes (5y, rep)

No

No

Yes (2.5y)

Yes (2y)

Yes (1y)

No

Yes (from first detection on)

Intermittent systemic steroids prior to first detection

Yes

Yes

No

Yes

Yes

No

No

Yes (from first detection on)

Lung function FEV 1 (% pred) **

Decline

Stable

Decline

Increase

Decline

Increase

Decline

Np

At first detection

61.2

49.3

81.2

84.3

86.3

68.2

40.1

61.3

At end of observation

43.1

47.2

57.3

88.3

79.0

79.6

30.0

Np

BMI (kg/m 2 ) ***

Decline

Stable

Increase

Increase

Increase

Increase

Decline

Np

At first detection

18.9

25.8

13.7

15.5

19.6

15.1

19.3

21.5

At end of observation

18.2

25.8

17.8

16.3

19.9

18

18.5

Np

IgG (g/l) ****

Increase+

Stable

increase

Stable

Stable

Stable

Increase

Np

At first detection

18.8

13.0

8.1

8.2

10.4

9.5

13.4

9.2

At end of observation

22.4

13.7

13.1

10.2

11.7

9.6

17.1

Np

CRP (mg/l)*****

Increase

Na

Increase

Stable

Stable

Stable

Decrease

Np

At first detection

6.2

11.1

<1.0

<1.0

3.5

<1.0

19.9

17.9

At end of observation

30.7

Na

11.7

<1.0

5.4

4.1

6.7

Np

  1. *years from first detection to Trichosporon to end of observation period, **change throughout the observation period of the individual patient, decline defined as ΔFEV1 > 1%pred/year, ***change in BMI throughout the observation period, ****change throughout the observation period, change defined as ΔIgG >3 g/l,, *****change throughout the observation period, change defined as ΔCRP >5 mg/l, + above reference range.
  2. Abbreviations: Na = not available, Nk = not known, np = not possible, chron = chronic, cont = continuous, rep = repeated, / = alternating, w = weeks, y = years, Acinet baum = Acinetobacter baumannii, Acinet fum = Acinetobacter fumigatus, Asp flav = Aspergillis flavipes, Asp fum = Aspergillus fumigatus, Burc cep = Burkholderia cepacia, Cand alb = Candida albicans, Cand glab = Candida glabrata, Cand paraps = Candida parapsilosis, Cefu = cefuroxim, Cep = ceporexin, Ceph = cephalexin, Cip = ciprofloxacin, Col = colistin, Cot = cotrimoxazole, E coli = Escherichia coli, Gern = gernebcin, Inqu lin = Inquilinus limosus, Nocard farc = Norcarderia facrinica, Pet sord = Petriella sordida, Penicill Sp = Penicillium sp, Prot mirab = Proteus mirabilis, Pseudoall boyd = Pseudoallescheria boydii, Ps ae = Pseudomonas aeruginosa, Ps ae muc = Pseudomonas aeruginosa mucoides, Ps put = Pseudomonas putida, Sa = Staphylococcus aureus, Sten malt = Stenotrophomonas maltophilia, Tob = tobramycin.