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Table 1 Characterization and follow-up of CF patients positive for Trichosporon

From: The basidiomycetous yeast Trichosporon may cause severe lung exacerbation in cystic fibrosis patients – clinical analysis of Trichosporonpositive patients in a Munich cohort

Patient number 1 2 3 4 5 6 7 8
Sex F M F M F F M F
Mutation dF508/ dF508 dF508/ dF508 dF508/ Nk dF508/ R553X dF508/ S466X dF508/ Nk dF508/ Nk dF508/ R553X
Age at first detection (y) 41.1 33.0 10.0 11.0 21.7 8.0 22.3 27.6
Age at last detection (y) 43.0 36.9 17.8 11.0 28.4 8.6 29.2 28.4
Follow up (y) * 3.1 5.9 7.8 2.4 6.7 5.3 6.9 0.8
Trichosporon species Nk Asahii Inkin Nk Mycotoxinivorans Nk Nk Nk
Other isolated organisms from sputum (at first detection) Ps ae (chron), Ps ae muc E col, Prot mirab None Norcard farc, Inqu lin, Burc cep, Asp fum, Penicill sp Ps ae (chron), Cand alb Acinet baum, fungi (not spec), Ps ae (chron) Ps ae (chron), Ps ae muc, Cand alb Ps ae muc (chron), Cand alb
Other isolated organisms from sputum (throughout observation period) Pseudoall boyd (rep), Cand glab (rep), Cand alb (rep), Cand paraps (rep), Enteroc spp. (rep), Asp fum (rep) Prot mirab (rep), Asp fum (rep) Asp fum (rep), Sten mal (rep), Cand alb (rep), Sa (rep) Inqu lin (rep), Burc cep (rep), Penicill sp (rep), Acinet fum (rep), Ps put (once) E coli (rep), Sten malt (rep), Asp flav (rep) Acinet baum (rep), Pet sord (rep) Asp fum (rep), Prot mirab (rep), Sa (rep), Enteroc spp (rep), Cand alb (rep) Cand paraps (rep)
Antibiotic regimen prior to first detection (agent; regimen)         
Oral Cip (cont) Cefur (cont), Cip (2 w on/off) Cep (cont), Cip (2 w on/off) Ceph (cont), Cip (2 w on/off) Ceph (cont) Ceph (cont), cip (2 w on/off) Ceph (cont) Cot (cont)
Inhaled Tob/col (2 w on/off) None Col (2 w on/off) Tob/col (2 w on/off) Gern (2 w on/off) None Gern (2 w on/off) Gern/col (2 w on/off)
iv (courses/y) 2 2 1 1 2 1 1 2
Diabetes mellitus (at first detection) Yes Yes no No No No No No
ABPA (years prior to first detection) 5y, 2y 3y no 3y, 1y No 1 y after first detection No At first detection
Nebulized/inhaled steroids prior to first detection (duration) Yes (5y, rep) No No Yes (2.5y) Yes (2y) Yes (1y) No Yes (from first detection on)
Intermittent systemic steroids prior to first detection Yes Yes No Yes Yes No No Yes (from first detection on)
Lung function FEV 1 (% pred) ** Decline Stable Decline Increase Decline Increase Decline Np
At first detection 61.2 49.3 81.2 84.3 86.3 68.2 40.1 61.3
At end of observation 43.1 47.2 57.3 88.3 79.0 79.6 30.0 Np
BMI (kg/m 2 ) *** Decline Stable Increase Increase Increase Increase Decline Np
At first detection 18.9 25.8 13.7 15.5 19.6 15.1 19.3 21.5
At end of observation 18.2 25.8 17.8 16.3 19.9 18 18.5 Np
IgG (g/l) **** Increase+ Stable increase Stable Stable Stable Increase Np
At first detection 18.8 13.0 8.1 8.2 10.4 9.5 13.4 9.2
At end of observation 22.4 13.7 13.1 10.2 11.7 9.6 17.1 Np
CRP (mg/l)***** Increase Na Increase Stable Stable Stable Decrease Np
At first detection 6.2 11.1 <1.0 <1.0 3.5 <1.0 19.9 17.9
At end of observation 30.7 Na 11.7 <1.0 5.4 4.1 6.7 Np
  1. *years from first detection to Trichosporon to end of observation period, **change throughout the observation period of the individual patient, decline defined as ΔFEV1 > 1%pred/year, ***change in BMI throughout the observation period, ****change throughout the observation period, change defined as ΔIgG >3 g/l,, *****change throughout the observation period, change defined as ΔCRP >5 mg/l, + above reference range.
  2. Abbreviations: Na = not available, Nk = not known, np = not possible, chron = chronic, cont = continuous, rep = repeated, / = alternating, w = weeks, y = years, Acinet baum = Acinetobacter baumannii, Acinet fum = Acinetobacter fumigatus, Asp flav = Aspergillis flavipes, Asp fum = Aspergillus fumigatus, Burc cep = Burkholderia cepacia, Cand alb = Candida albicans, Cand glab = Candida glabrata, Cand paraps = Candida parapsilosis, Cefu = cefuroxim, Cep = ceporexin, Ceph = cephalexin, Cip = ciprofloxacin, Col = colistin, Cot = cotrimoxazole, E coli = Escherichia coli, Gern = gernebcin, Inqu lin = Inquilinus limosus, Nocard farc = Norcarderia facrinica, Pet sord = Petriella sordida, Penicill Sp = Penicillium sp, Prot mirab = Proteus mirabilis, Pseudoall boyd = Pseudoallescheria boydii, Ps ae = Pseudomonas aeruginosa, Ps ae muc = Pseudomonas aeruginosa mucoides, Ps put = Pseudomonas putida, Sa = Staphylococcus aureus, Sten malt = Stenotrophomonas maltophilia, Tob = tobramycin.