Gene | SNP | Genotype | N | Mean ± SE Baseline FEV1(% predicted) | p-value*a | p-value*b | N | Mean ± SE Rate of Decline in FEV1(% predicted) | p-value*a | p-value*b |
---|---|---|---|---|---|---|---|---|---|---|
NOS1 | rs41279104 | CC | 2650 (79%) | 78.39 ± 0.17 | Referent | 0.1424 | 2602 (79%) | -0.97 ± 0.04 | Referent | 0.3530 |
CT | 650(19%) | 78.84 ± 0.37 | 0.7688 | 635 (19%) | -1.02 ± 0.07 | 0.5332 | ||||
TT | 55 (2%) | 79.33 ± 1.19 | 0.3825 | 52 (2%) | -1.27 ± 0.26 | 0.3434 | ||||
NOS2 | rs8078340 | GG | 2760 (76%) | 78.64 ± 0.17 | Referent | 0.1118 | 2705 (76%) | -0.96 ± 0.03 | Referent | 0.1838 |
AG | 794 (22%) | 78.28 ± 0.32 | 0.7166 | 781 (22%) | -1.03 ± 0.07 | 0.8221 | ||||
AA | 81 (2%) | 77.82 ± 1.00 | 0.2977 | 81 (2%) | -1.12 ± 0.20 | 0.4215 | ||||
NOS3 | rs1800779 | AA | 1448 (41%) | 77.97 ± 0.24 | Referent | 0.0018 | 1425 (41%) | -1.05 ± 0.05 | Referent | 0.3838 |
AG | 1552 (44%) | 78.81 ± 0.23 | 0.8034 | 1521 (44%) | -0.92 ± 0.05 | 0.1149 | ||||
GG | 516 (15%) | 79.31 ± 0.39 | 0.0273 | 504 (15%) | -1.02 ± 0.07 | 0.7133 |