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Table 6 Genetic association of NOS3 rs1800779 SNP with FEV 1 % predicted in each casecontrol study

From: Nitric oxide synthase polymorphisms, gene expression and lung function in chronic obstructive pulmonary disease

Group Genotype COPDGene β coefficient (SE) p-value* ECLIPSE β coefficient (SE) p-value* NETT/NAS β coefficient (SE) p-value* GenKOLS β coefficient (SE) p-value* Meta-analysis β coefficient (SE) p-value*
Cases AA Referent Referent Referent Referent Referent
AG 0.75 (1.84) 0.68 -1.43 (0.85) 0.09 -1.46 (0.84) 0.08 1.50 (1.30) 0.25 0.80 (0.52) 0.12
GG 2.08 (2.60) 0.42 -0.52 (1.23) 0.67 -1.42 (1.17) 0.23 -2.03 (2.04) 0.32 -0.88 (0.75) 0.24
Controls AA Referent Referent Referent Referent Referent
AG 1.69 (1.10) 0.12 3.53 (2.35) 0.13 -0.49 (1.37) 0.72 -0.98 (0.68) 0.15 -0.09 (0.52) 0.86
GG -0.73 (1.64) 0.66 0.36 (3.47) 0.92 -1.62 (1.81) 0.37 -0.12 (1.05) 0.91 -0.51 (0.78) 0.51
  1. *p values were adjusted for age, pack-years of cigarette smoking, and genetic ancestry.