Table 6 Genetic association of NOS3 rs1800779 SNP with FEV 1 % predicted in each case–control study
Group | Genotype | COPDGene β coefficient (SE) p-value* | ECLIPSE β coefficient (SE) p-value* | NETT/NAS β coefficient (SE) p-value* | GenKOLS β coefficient (SE) p-value* | Meta-analysis β coefficient (SE) p-value* |
|---|---|---|---|---|---|---|
Cases | AA | Referent | Referent | Referent | Referent | Referent |
AG | 0.75 (1.84) 0.68 | -1.43 (0.85) 0.09 | -1.46 (0.84) 0.08 | 1.50 (1.30) 0.25 | 0.80 (0.52) 0.12 | |
GG | 2.08 (2.60) 0.42 | -0.52 (1.23) 0.67 | -1.42 (1.17) 0.23 | -2.03 (2.04) 0.32 | -0.88 (0.75) 0.24 | |
Controls | AA | Referent | Referent | Referent | Referent | Referent |
AG | 1.69 (1.10) 0.12 | 3.53 (2.35) 0.13 | -0.49 (1.37) 0.72 | -0.98 (0.68) 0.15 | -0.09 (0.52) 0.86 | |
GG | -0.73 (1.64) 0.66 | 0.36 (3.47) 0.92 | -1.62 (1.81) 0.37 | -0.12 (1.05) 0.91 | -0.51 (0.78) 0.51 |