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Table 4 Experiment 2: Cytokine and chemokine levels measured in lung perfusate at the end of MV

From: The effects of exogenous surfactant administration on ventilation-induced inflammation in mouse models of lung injury

 

Air

Acid

Mediator (pg/ml)

No treatment

bLES

No treatment

bLES

Eotaxin

17.4 ± 1.3

25.7 ± 0.9

135.2 ± 13.6*

142.8 ± 15.9*

G-CSF

45.9 ± 10.5

59.4 ± 3.4

890.8 ± 75.8

1270.3 ± 187.8*

GM-CSF

0

0

13.4 ± 2.8

16.3 ± 2.2

IL-6

567.7 ± 62.7

1119.0 ± 99.1

8303.2 ± 323.6*

10720.1 ± 764.2*

IL-1 β

1.0 ± 0.40

0.2 ± 0.1

0.3 ± 0.1

3.2 ± 0.6

KC

579.2 ± 65.8

907.0 ± 75.4

3617.2 ± 174.3*

6212.7 ± 504.8*

LIX

113.7 ± 11.1

98.3 ± 13.0

284.6 ± 17.9

447.4 ± 31.9*

MCP-1

12.9 ± 1.8

30.9 ± 4.9

337.4 ± 26.2

558.0 ± 71.5*

MIP-2

584.4 ± 68.2

725.7 ± 41.9

1840.2 ± 76.7*

3113.4 ± 204.8*,#

TNF-α

63.4 ± 11.6

72.2 ± 7.0

119.7 ± 3.1

143.3 ± 8.1

IP-10

32.9 ± 3.6

40.8 ± 1.7

391.3 ± 80.8

283.3 ± 27.7

  1. G-CSF = granulocyte colony-stimulating factor, GM-CSF = granulocyte-macrophage CSF, IL-6 = interleukin-6, IP-10 = interferon-γ-induced protein 10, KC = keratinocyte chemoattractant, LIX = lipopolysaccharide-induced CXC chemokine, MCP-1 = monocyte chemotactic protein-1, MIP-2 = macrophage inflammatory protein 2 and TNF-α = tumor necrosis factor-alpha.
  2. Data are expressed as mean ± SEM; n = 6 per group. *p > 0.05 versus respective Air control, #p < 0.05 versus Acid No Treatment.