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Table 4 Experiment 2: Cytokine and chemokine levels measured in lung perfusate at the end of MV

From: The effects of exogenous surfactant administration on ventilation-induced inflammation in mouse models of lung injury

  Air Acid
Mediator (pg/ml) No treatment bLES No treatment bLES
Eotaxin 17.4 ± 1.3 25.7 ± 0.9 135.2 ± 13.6* 142.8 ± 15.9*
G-CSF 45.9 ± 10.5 59.4 ± 3.4 890.8 ± 75.8 1270.3 ± 187.8*
GM-CSF 0 0 13.4 ± 2.8 16.3 ± 2.2
IL-6 567.7 ± 62.7 1119.0 ± 99.1 8303.2 ± 323.6* 10720.1 ± 764.2*
IL-1 β 1.0 ± 0.40 0.2 ± 0.1 0.3 ± 0.1 3.2 ± 0.6
KC 579.2 ± 65.8 907.0 ± 75.4 3617.2 ± 174.3* 6212.7 ± 504.8*
LIX 113.7 ± 11.1 98.3 ± 13.0 284.6 ± 17.9 447.4 ± 31.9*
MCP-1 12.9 ± 1.8 30.9 ± 4.9 337.4 ± 26.2 558.0 ± 71.5*
MIP-2 584.4 ± 68.2 725.7 ± 41.9 1840.2 ± 76.7* 3113.4 ± 204.8*,#
TNF-α 63.4 ± 11.6 72.2 ± 7.0 119.7 ± 3.1 143.3 ± 8.1
IP-10 32.9 ± 3.6 40.8 ± 1.7 391.3 ± 80.8 283.3 ± 27.7
  1. G-CSF = granulocyte colony-stimulating factor, GM-CSF = granulocyte-macrophage CSF, IL-6 = interleukin-6, IP-10 = interferon-γ-induced protein 10, KC = keratinocyte chemoattractant, LIX = lipopolysaccharide-induced CXC chemokine, MCP-1 = monocyte chemotactic protein-1, MIP-2 = macrophage inflammatory protein 2 and TNF-α = tumor necrosis factor-alpha.
  2. Data are expressed as mean ± SEM; n = 6 per group. *p > 0.05 versus respective Air control, #p < 0.05 versus Acid No Treatment.