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Table 4 Rate of hospitalizations for asthma patients in Canada

From: Clinical, economic, and humanistic burden of asthma in Canada: a systematic review

Study

Number of patients

Patient descriptor

Year

Hospitalizations for asthma

Per patient per year

Per 1000 patients per year

Children

Blais et al. 2011 [43]

7,494

≥1 exacerbations in the year prior to treatment initiation, ICS

1998-2005

0.03

 

≥1 exacerbations in the year prior to treatment initiation, LTRA

0.06

 

19,861

No exacerbation in the year prior to treatment initiation: ICS

0.005

 

No exacerbation in the year prior to treatment initiation: LTRA

0.003

 

Ungar et al. 2011 [21]

490

Asthmatic children

2000-2003

0.25§

 

To et al. 2008 [24]

56,737

0-2 years

1998/1999

 

86.7

99,163

3-5 years

 

27.3

141,305

6-9 years

 

10.9

297,205

Overall

 

30.9

To et al. 2007 [26]

34,216

Persistent asthma

1994-2006

 

63*

Remission asthma

 

39*

Overall

 

52*

Ungar et al. 2001 [33]

339

Asthma children

1995

1

 

Adults

Sadatsafavi et al. 2010 [10]

158,516

Narrow asthma definition€

1996-2000

0.016

 

Broad asthma definition¥

0.03

 

Lemiere et al. 2007 [25]

351 (WEA: 145, OA: 206)

WRA

2001-2003

0.04(0.2)

 

NWRA

0.008(0.7)

 

Anis et al. 2001 [38]

4,671

Appropriate use†

1995

0.07(0.34)

 

763

Inappropriate use‡

0.11(0.42)

 

All ages

Disano et al. 2010 [22]

NR

High SES

2003-2006

 

1.61**

Average SES

 

1.95**

Low SES

 

2.7**

Klomp et al. 2008 [36]

24,616 (24,180 of whom were still alive and living in the region the following year)

Asthma patients

2002/2003 and 2003/2004

 

10.9

Lougheed et al. 2006 [28]

574,304 children and 1,194,095 adults in Ontario

Patients with an ED disposition diagnosis of asthma in a stratified sample of 16 hospitals

2001-2002

 

108 (10.8%) children; 69 (6.9%) adults

Suissa et al. 2002 [41]

30,569

Source cohort††

1975-1997

 

48

4,673

Full cohort‡‡

 

42.4

Seung et al. 2005 [42]

NR

Asthma patients

2004

 

1.43**

  1. §Calculated as 124 hospitalizations for 490 patients.
  2. *Calculated as the rate per 100 patients x 10.
  3. **Calculated as (the rate per 100,000 patients) / 100.
  4. €Narrow asthma definition: ICD-9 493.x.
  5. ¥Broad asthma definition: visits for an asthma-related diagnosis; hospitalizations with asthma among the discharge diagnoses.
  6. †Appropriate use (low-dose SABA + high-dose ICS).
  7. ‡Inappropriate use (high-dose SABA + low-dose ICS).
  8. ††Source cohort: subjects 5–44 years receiving ≥3 prescriptions of an anti-asthma medication (beclomethasone, budesonide, epinephrine bitartrate, fenoterol, flunisolide, ipratropium bromide, isoproterenol, ketotifen, metaproterenol, nedocromil, procaterol, salbutamol, sodium cromoglycate, terbutaline, triamcinolone acetate, or any compound of theophylline) in any 1 year period.
  9. ‡‡Full cohort: all subjects with at least 1 year follow up, irrespective of whether or not they were admitted to hospital for asthma during the baseline year.
  10. NWRA=non-work-related asthma; WRA=work-related asthma.