| |
Quartile 1 (4.1 – 8.04 m/s) n = 38
|
Quartile 2 (8.05 – 9.69 m/s) n = 36
|
Quartile 3 (9.7 – 11.74 m/s) n = 41
|
Quartile 4 (>11.75 m/s) n = 38
|
|---|
|
Age (years) ¥
|
59.4 (7.2)
|
61.7 (6.9)
|
63.6 (7.7)*
|
68.1 (8.4)**
|
|
Male, n (%)
|
20 (53)
|
17 (47)
|
22 (54)
|
24 (63)
|
|
Race, Caucasian, n (%)
|
34 (89)
|
33 (92)
|
39 (95)
|
36 (95)
|
|
BMI (kg/m2)
|
26.4 (4.8)
|
27.2 (4.9)
|
26.1 (4.6)
|
28.0 (4.7)
|
|
Current smoker, n (%)
|
13 (34)
|
18 (50)
|
20 (49)
|
26 (68)*
|
|
Total pack-years
|
55.32 (29.81)
|
48.75 (23.67)
|
55.56 (20.59)
|
66.92 (38.69)
|
|
FEV1 (%predicted)
|
52.99 (15.17)
|
59.56 (13.43)
|
55.18 (15.36)
|
54.26 (15.97)
|
|
FEV1 (L)
|
1.61 (0.62)
|
1.76 (0.62)
|
1.60 (0.58)
|
1.54 (0.57)
|
|
Cardiovascular disease, n (%)
|
10 (26)
|
8 (22)
|
14 (34)
|
21 (55)*
|
|
Diabetes mellitus, n (%)
|
8 (21)
|
11 (31)
|
10 (24)
|
17 (45)
|
|
Heart Rate (per minute)
|
69.6 (10.3)
|
69.1 (11.1)
|
68.5 (13.4)
|
71.2 (8.8)
|
|
Systolic blood pressure (mmHg) ¥
|
120.5 (17.3)
|
125.9 (14.1)
|
128.8 (17.2)*
|
134.7 (16.8)**
|
|
Diastolic blood pressure (mmHg)
|
75.9 (10.1)
|
78.1 (11.1)
|
75.7 (8.3)
|
78.6 (9.3)
|
|
Log TAC
|
6.28 (2.16)
|
6.17 (2.17)
|
7.20 (1.97)*
|
7.64 (1.31)**
|
|
Log CAC
|
5.43 (1.80)
|
5.10 (2.44)
|
5.71 (1.97)
|
5.66 (2.05)
|
|
aPWV (m/s)
|
6.7 (1.1)
|
8.8 (0.4)
|
10.6 (0.5)
|
13.7 (2.1)
|
|
%emphysema on CT
|
7.2 (9.1)
|
6.6 (9.3)
|
11.1 (14.1)
|
10.3 (11.7)
|
|
LDL cholesterol (mmol/L)
|
2.56 (1.04)
|
2.66 (0.98)
|
2.61 (0.93)
|
2.60 (1.03)
|
|
HDL cholesterol (mmol/L)
|
1.42 (0.53)
|
1.51 (0.68)
|
1.52 (0.47)
|
1.35 (0.41)
|
|
Total cholesterol (mmol/L)
|
4.75 (0.97)
|
4.86 (1.10)
|
4.93 (1.18)
|
4.70 (1.16)
|
|
Log hsCRP (mg/L)
|
0.95 (0.88)
|
0.76 (0.95)
|
1.08 (1.02)
|
1.28 (1.12)
|
|
Log fibrinogen (mg/dl)
|
1.10 (0.21)
|
0.98 (0.28)*
|
1.07 (0.29)
|
1.08 (0.20)
|
- *p<0.05. ** p<0.01 for quartiles compared with quartile 1.
- ¥ p<0.01 on multivariate analyses for quartile 4 compared with quartile 1.
- All values expressed as mean (standard deviation) unless otherwise specified.
- Definition of abbreviations: BMI body mass index, FEV
1 forced expiratory volume in the first 1 second, TAC thoracic aortic calcification, CAC coronary arterial calcification, aPWV aortic pulse wave velocity, CT computed tomography, LDL low density lipoprotein, HDL high density lipoprotein, hsCRP high sensitivity C-reactive protein.
