
AATD + AUG^{a}

AATDAUG^{b}

AATD PFTnorm^{c}

nonAATD COPD^{d}

Healthy^{e}


FVC (liters)

3.85 ± 0.42

2.88 ± 0.16^{c}

4.27 ± 0.64^{e}

2.80 ± 0.32^{c,e}

3.96 ± 0.57^{d}

FVC (% pred)

88 ± 6^{c}

79 ± 5^{c}

109 ± 6^{e}

77 ± 8^{c,e}

95 ± 6^{d}

FEV1 (liters)

1.23 ± 0.25^{c,e}

1.35 ± 0.22^{c,e}

3.22 ± 0.47^{e}

1.49 ± 0.11^{c,e}

3.07 ± 0.35^{d}

FEV1 (% pred)

35 ± 5^{c,e}

47 ± 7^{c,e}

107 ± 4^{e}

54 ± 7^{c,e}

93 ± 4^{d}

FEV1/FVC

31 ± 3^{c,d,e}

47 ± 7^{c,e}

76 ± 7^{c,e}

56 ± 4^{c,e}

79 ± 2^{d}

FEV1/FVC (% pred)

40 ± 4^{c,d,e}

61 ± 10^{c,e}

97 ± 2^{e}

71 ± 6^{c,e}

99 ± 3^{d}

Bike (twolegs) exercise
     
Watts

62 ± 6^{c,e}

46 ± 11^{c,e}

176 ± 47^{d,e}

70 ± 11^{c,e}

126 ± 17^{d}

VO2peak (L/min)

1.02 ± 0.11^{c,e}

0.69 ± 0.13^{c,e}

2.07 ± 0.51^{d}

1.16 ± 0.12^{c,e}

1.71 ± 0.25^{d}

VO2peak (ml/kg/min)

12.6 ± 0.5^{c}

9.5 ± 1.1^{c,e}

26.9 ± 5.6^{d,e}

14.9 ± 1.7^{c}

20.3 ± 3.3

Knee extensor (singleleg) exercise
     
Watts

25 ± 3^{c}

21 ± 7^{c}

59 ± 23^{d,e}

21 ± 3^{c}

26 ± 1

Smoking history
     
Never

17%

0%

25%

0%

0%

Exsmoker

83%

100%

75%

43%

100%

Current

0%

0%

0%

57%

0%

 Data are mean ± SE. AATD, alpha1 antitrypsin deficient; AUG, augmentation therapy; PFTnorm, pulmonary function testing normal; AAT, alpha1 antitrypsin; COPD, chronic obstructive pulmonary disease; FVC, forced vital capacity; FEV1, forced expiratory volume at 1 sec; VO2peak, peak oxygen consumption during exercise. Significance difference between group is denoted as follows, ‘^{c}’ different compared to AATD PFTnorm,‘^{d}’ different compared to COPD, ‘^{e}’ different compared to Healthy. No differences with respect to AATD + AUG ‘^{a}’ or AATDAUG ‘^{b}’ were found. In all cases, significance is p ≤ 0.05.