The Cohort for Childhood Origin of Asthma and allergic diseases (COCOA) study: design, rationale and methods

Yang, Hyeon-Jong; Lee, So-Yeon; Suh, Dong In; Shin, Youn Ho; Kim, Byoung-Ju; Seo, Ju-Hee; Chang, Hyoung Yoon; Kim, Kyung Won; Ahn, Kangmo; Shin, Yee-Jin; Lee, Kyung-Sook; Lee, Cheol Min; Oh, Se-Young; Kim, Ho; Leem, Jong-Han; Kim, Hwan-Cheol; Kim, Eun-Jin; Lee, Joo-Shil; Hong, Soo-Jong

doi:10.1186/1471-2466-14-109

BMC Pulmonary Medicine

Table 1 Data collection schedule of the COhort for Childhood Origin of Asthma and allergic diseases (COCOA) study

From: The Cohort for Childhood Origin of Asthma and allergic diseases (COCOA) study: design, rationale and methods

					Scheduled visits of the mother-child pair when the child is the indicated age
	Enrollment (26^thGA)	36^thGA	Birth	1 mo	6 mo	1 yr	2 yrs	3 yrs	4 yrs	5 yrs	6 yrs	7 yrs	8 yrs	9 yrs	10 yrs
Informed consent	√		√
General questionnaire
Maternal eligibility	√	√
Familial demographics	√										√
Familial socioeconomic status	√										√
Familial history of allergic and respiratory diseases	√										√
Maternal health questionnaires
Maternal general health	√	√	√
Maternal life style	√	√	√
Maternal diet/nutrition	√	√	√
Maternal psychosocial stress		√			√	√	√	√	√		√
Child’s health questionnaire					√	√	√	√	√	√	√	√	√	√	√
Child’s general health					√	√	√	√	√	√	√	√	√	√	√
Child’s diet/nutrition					√	√		√			√		√	√	√
Child’s medication					√	√	√	√	√	√	√	√	√	√	√
Child’s allergic and respiratory illness					√	√	√	√	√	√	√	√	√	√	√
Child’s psychological development					√	√	√	√	√		√		√	√	√
Physician’s examination of child			√		√	√	√	√	√	√	√	√	√	√	√
Clinical measurement
SCORAD index					√	√	√	√	√	√	√	√	√	√	√
Allergy skin test
Mother					√
Father			√
Child								√			√			√
Spirometryof child												√
IOS of child									√
FeNO of child										√
Methacholine challenge test											√			√
Respiratory virus (nasopharyngeal aspiration)			At every episode of respiratory viral illness
Blood sampling
Maternal blood					√
Paternal blood			√
Cord blood			√
Child’s blood			√			√		√			√			√*
Urine sampling of child								√			√			√
Feces sampling of child				√	√			√			√
Skin microbiome of child					√			√			√
X-ray (bone-age) of child												√
Questionnaire about the indoor environment
Indoor environment assessment		√			√	√	√	√	√	√	√	√	√	√	√
Dust sample collection		√			√
Indoor air-pollutant measurements		√
Microbial sample collection		√			√
Outdoor air-pollutant assessment		√			√

*LH, FSH measurement at 9 years of age.
Abbreviations: FeNO Fractional exhaled nitric oxide, FSH Follicle-Stimulating hormone, GA Gestational age, IOS Impulse oscillometry, LH Luteinizing hormone, SCORAD Scoring atopic dermatitis.

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ISSN: 1471-2466

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