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Table 1 Data collection schedule of the COhort for Childhood Origin of Asthma and allergic diseases (COCOA) study

From: The Cohort for Childhood Origin of Asthma and allergic diseases (COCOA) study: design, rationale and methods

      Scheduled visits of the mother-child pair when the child is the indicated age
  Enrollment (26thGA) 36thGA Birth 1 mo 6 mo 1 yr 2 yrs 3 yrs 4 yrs 5 yrs 6 yrs 7 yrs 8 yrs 9 yrs 10 yrs
Informed consent               
General questionnaire                
Maternal eligibility              
Familial demographics               
Familial socioeconomic status               
Familial history of allergic and respiratory diseases               
Maternal health questionnaires                
Maternal general health             
Maternal life style             
Maternal diet/nutrition             
Maternal psychosocial stress            
Child’s health questionnaire     
Child’s general health     
Child’s diet/nutrition            
Child’s medication     
Child’s allergic and respiratory illness     
Child’s psychological development         
Physician’s examination of child     
Clinical measurement                
SCORAD index     
Allergy skin test                
Mother                
Father                
Child                
Spirometryof child                
IOS of child                
FeNO of child                
Methacholine challenge test                
Respiratory virus (nasopharyngeal aspiration)    At every episode of respiratory viral illness        
Blood sampling                
Maternal blood                
Paternal blood                
Cord blood                
Child’s blood               *  
Urine sampling of child                
Feces sampling of child               
Skin microbiome of child                
X-ray (bone-age) of child                
Questionnaire about the indoor environment                
Indoor environment assessment     
Dust sample collection                
Indoor air-pollutant measurements                
Microbial sample collection                
Outdoor air-pollutant assessment                
  1. *LH, FSH measurement at 9 years of age.
  2. Abbreviations: FeNO Fractional exhaled nitric oxide, FSH Follicle-Stimulating hormone, GA Gestational age, IOS Impulse oscillometry, LH Luteinizing hormone, SCORAD Scoring atopic dermatitis.