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Table 1 Selection criteria

From: Epigenetics modifications and Subclinical Atherosclerosis in Obstructive Sleep Apnea: The EPIOSA study

Inclusion criteria Exclusion criteria
Males aged 20 – 60 years Any history of cigarette/tobacco smoking use
AHI ≥ 5 events per hour of sleep (OSA group) and AHI < 5 (control group) Alcohol abuse
Willingness to participate in the study and complying with the study by signing a written informed consent Arterial blood hypertension (arterial blood pressure: ≥140 mmHg systolic and/or ≥90 mmHg diastolic or taking antihypertensive medication)
  Low high-density lipoprotein (HDL) cholesterol (<40 mg/dL) or high LDL cholesterol (≥130 mg/dL) or taking lower lipid drugs.
Available for study visits over 5 years Fasting plasma glucose >126 mg/dl or taking anti diabetic medications
Other metabolic diseases (e.g., hypothyroidism)
Present or past history of vascular diseases, including myocardial infarction, angina, coronary artery procedures (coronary artery bypass graft or percutaneous coronary intervention), aneurysm, transient ischemic attack or stroke.
Autoimmune diseases
Past or present history of malignancies
Chronic inflammatory diseases (e.g., Crohn disease)
Chronic infectious diseases (e.g., chronic viral hepatitis)
Chronic respiratory diseases (e.g., asthma)
Morbid obesity (body mass index ≥40 kg/m2)
Any chronic oral therapy
Sleep disorders other than OSA
Having undergone upper airway surgery
Having previously use CPAP therapy