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Table 1 Selection criteria

From: Epigenetics modifications and Subclinical Atherosclerosis in Obstructive Sleep Apnea: The EPIOSA study

Inclusion criteria

Exclusion criteria

ā— Males aged 20 ā€“ 60 years

ā— Any history of cigarette/tobacco smoking use

ā— AHIā€‰ā‰„ā€‰5 events per hour of sleep (OSA group) and AHIā€‰<ā€‰5 (control group)

ā— Alcohol abuse

ā— Willingness to participate in the study and complying with the study by signing a written informed consent

ā— Arterial blood hypertension (arterial blood pressure: ā‰„140 mmHg systolic and/or ā‰„90 mmHg diastolic or taking antihypertensive medication)

 

Low high-density lipoprotein (HDL) cholesterol (<40 mg/dL) or high LDL cholesterol (ā‰„130 mg/dL) or taking lower lipid drugs.

ā— Available for study visits over 5 years

ā— Fasting plasma glucose >126 mg/dl or taking anti diabetic medications

ā— Other metabolic diseases (e.g., hypothyroidism)

ā— Present or past history of vascular diseases, including myocardial infarction, angina, coronary artery procedures (coronary artery bypass graft or percutaneous coronary intervention), aneurysm, transient ischemic attack or stroke.

ā— Autoimmune diseases

ā— Past or present history of malignancies

ā— Chronic inflammatory diseases (e.g., Crohn disease)

ā— Chronic infectious diseases (e.g., chronic viral hepatitis)

ā— Chronic respiratory diseases (e.g., asthma)

ā— Morbid obesity (body mass index ā‰„40 kg/m2)

ā— Any chronic oral therapy

ā— Sleep disorders other than OSA

ā— Having undergone upper airway surgery

ā— Having previously use CPAP therapy