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Table 2 Outcome measurements in the Epigenetics in Obstructive Sleep Apnea (EPIOSA) study

From: Epigenetics modifications and Subclinical Atherosclerosis in Obstructive Sleep Apnea: The EPIOSA study

Measurement Description Frequency of assessment
Questionnaires, Dietary, Epworth Sleepiness Scale   Each visit
Vital signs Including sitting blood pressure, heart rate, height and weight Each visit
Exhaled carbon monoxide Confirmation of smoking status Each visit
Spirometry Post-bronchodilator FVC, FEV1 and FEV1/FVC Baseline
Electrocardiogram 12-lead resting electrocardiogram Baseline
Sleep Study At home type 3 monitor for diagnosis and at home autoCPAP for CPAP titration (if appropriated) Baseline and every year
Blood sample Standard biochemistry and lipid markers: Total cholesterol, LDL, HDL, TG, Apo A, Apo B. Baseline and last visit
Inflammatory markers: TNF-α, IFN-ϒ, IL-1β, IL-6, IL-8, IL-10.
Urine sample Microalbuminuria, 8-isoprostane Baseline and every year
Carotid Ultrasonography High-resolution B-mode assessment of carotid artery intima-media thickness and plaque Baseline and every year
Magnetic resonance imaging Cerebral microbleeds detection Baseline and last visit
Flow cytometry Fresh peripheral blood T-cell phenotype Baseline and last visit
DNA methylation Genome-wide DNA methylation status Baseline and last visit
miRNA microarray analysis Levels of candidate miRNAs regulated by aberrant DNA methylation Baseline and last visit