Measurement | Description | Frequency of assessment |
---|---|---|
Questionnaires, Dietary, Epworth Sleepiness Scale | Ā | Each visit |
Vital signs | Including sitting blood pressure, heart rate, height and weight | Each visit |
Exhaled carbon monoxide | Confirmation of smoking status | Each visit |
Spirometry | Post-bronchodilator FVC, FEV1 and FEV1/FVC | Baseline |
Electrocardiogram | 12-lead resting electrocardiogram | Baseline |
Sleep Study | At home type 3 monitor for diagnosis and at home autoCPAP for CPAP titration (if appropriated) | Baseline and every year |
Blood sample | Standard biochemistry and lipid markers: Total cholesterol, LDL, HDL, TG, Apo A, Apo B. | Baseline and last visit |
Inflammatory markers: TNF-Ī±, IFN-Ļ, IL-1Ī², IL-6, IL-8, IL-10. | ||
Urine sample | Microalbuminuria, 8-isoprostane | Baseline and every year |
Carotid Ultrasonography | High-resolution B-mode assessment of carotid artery intima-media thickness and plaque | Baseline and every year |
Magnetic resonance imaging | Cerebral microbleeds detection | Baseline and last visit |
Flow cytometry | Fresh peripheral blood T-cell phenotype | Baseline and last visit |
DNA methylation | Genome-wide DNA methylation status | Baseline and last visit |
miRNA microarray analysis | Levels of candidate miRNAs regulated by aberrant DNA methylation | Baseline and last visit |