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Table 4 Serum TAS, lung GSH content, and anitixoidative enzyme activity a

From: Short-term glutamine supplementation decreases lung inflammation and the receptor for advanced glycation end-products expression in direct acute lung injury in mice

 

Unchallenged

ALI

pvalues from Two-way ANOVAb

Control

GLN

Control

GLN

ALI

GLN

ALI × GLN

Serum TAS (mM)

1.13 ± 0.11

1.11 ± 0.17

1.04 ± 0.07

1.07 ± 0.11

NS.

NS.

NS.

GSH (μmol/g Lung)

4.57 ± 2.44

4.62 ± 2.72

3.89 ± 2.99

6.42 ± 2.52

NS.

NS.

NS.

Catalase (unit/mg protein)

29.1 ± 2.4

29.1 ± 2.5

21.3 ± 2.1

22.3 ± 2.4

< 0.001

NS.

NS.

GR (unit/g protein)

30.6 ± 3.6

31.5 ± 2.6

27.3 ± 3.3

28.5 ± 2.6

< 0.05

NS.

NS.

GST (unit/mg protein)

0.39 ± 0.08

0.41 ± 0.08

0.28 ± 0.04

0.30 ± 0.04

< 0.001

NS.

NS.

SOD (unit/mg protein)

3.07 ± 0.26

3.32 ± 0.24

3.23 ± 0.36

3.28 ± 0.47

NS.

NS.

NS.

Se-GPx (unit/g protein)

44.8 ± 6.4

45.4 ± 9.1

37.4 ± 5.3

43.6 ± 5.4

0.05

NS.

NS.

  1. aEach value represents Mean ± S.D., n = 10-12. NS., no significant difference; GSH, glutathione; GR, glutathione reductase; GST, glutathione S-transferase; Se-GPx, se-dependent glutathione peroxidase; SOD, superoxide dismutase; TAS, total antioxidant system.
  2. bThe significance of differences among four groups were analyzed by two-way ANOVA . Values not sharing a same superscript letters in the horizontal row are significantly different from one another by Duncan’s Multiple Range Test (P < 0.05).
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BMC Pulmonary Medicine

ISSN: 1471-2466

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