Nanoparticle uptake by airway phagocytes after fungal spore challenge in murine allergic asthma and chronic bronchitis

Table 2 Sizes of vesicles and internalized particles

Animals	Single NP	Vesicle	R_V/P	Cluster	Vesicle	R_V/P	Cluster	Vesicle	R_V/P	Cluster	Vesicle	R_V/P
Animals	Single NP	_{1 NP}	R_V/P	_{2-5 NP}	_{2-5 NP}	R_V/P	_{6-10 NP}	_{6-10 NP}	R_V/P	_{> 10 NP}	_{> 10 NP}	R_V/P
OVA-allergic	22.2 ± 1.4	466 ± 64	20.8 ± 2.5	43.4 ± 2.3	459 ± 53	11.1 ± 1.2	78.7 ± 3.3	401 ± 38	5.1 ± 0.4	156 ± 9	393 ± 25	2.7 ± 0.2
	(n = 16)			(n = 26)			(n = 22)			(n = 38)
Sham	21.0 ± 0.7	367 ± 38	17.9 ± 1.9	48.6 ± 3.3	338 ± 41	7.7 ± 1.3	83.5 ± 6.5	414 ± 34	5.2 ± 0.5	182 ± 19	393 ± 32	2.4 ± 0.2
	(n = 22)			(n = 28)			(n = 22)			(n = 30)
Scnn1b-Tg	21.5 ± 0.3	435 ± 30	20.5 ± 1.4	47.9 ± 2.5	393 ± 22	9.4 ± 0.6	74.0 ± 3.3	366 ± 25	5.3 ± 0.4	149 ± 7^*	420 ± 19	3.1 ± 0.2
	(n = 69)			(n = 87)			(n = 49)			(n = 77)
WT	22.5 ± 0.4	543 ± 61	24.5 ± 2.8	50.4 ± 3.3	451 ± 43	10.3 ± 1.1	79.1 ± 3.7	404 ± 33	5.3 ± 0.5	188 ± 9	460 ± 20	2.7 ± 0.2
	(n = 46)			(n = 57)			(n = 34)			(n = 74)

Data are presented as mean values ± SEM. ^*Significant difference to control group (P = 0.005); n = number of measurements (vesicle and enclosed AuNP). R_V/P = ratio of vesicle to particle diameter.

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