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Table 3 Dependence of R V/P on health status, disease model/mouse strain and AuNP uptake

From: Nanoparticle uptake by airway phagocytes after fungal spore challenge in murine allergic asthma and chronic bronchitis

Animal group/Vesicle class Fixed effect estimates
Value SE DF P-value
(Intercept ) 2.941 0.103 677 0.000
Healthy (Sham, WT) -0.137 0.129 13 0.307
COPD model (Scnn1b-Tg, WT) -0.044 0.118 13 0.717
Healthy, COPD model (WT) 0.172 0.162 13 0.309
Vesicle class B (2 - 5 NP) -0.817 0.056 677 0.000*
Vesicle class C (6 - 10 NP) -1.351 0.063 677 0.000*
Vesicle class D (> 10 NP) -2.004 0.055 677 0.000*
  1. The estimates of the linear mixed effects model revealed no significant difference between (i) the healthy and diseased animals, (ii) the disease model, the two mouse strains or (iii) the diseased animals of the two groups on the log of the ratio of vesicle to particle diameter, log(RV/P). *Significant vesicle class effect (P < 0.05), i.e. effect of not being in vesicle class A but in the respective category B, C or D; thus RV/P decreases with increasing number of nanoparticles. SE = standard error; DF = degrees of freedom.