Parameter | Arithmetic mean (CV%) | |||
---|---|---|---|---|
GP MDI 14.4 μg | GP MDI 28.4 μg | GP MDI 57.6 μg | GP MDI 115.2 μg | |
N | 18 | 18 | 20 | 20 |
AUC0–24 (pg•h/mL) | 34.5 (101.2) | 120 (67.2) | 202 (74.5) | 498 (82.0) |
AUC0–12 (pg•h/mL) | 31.9 (88.8) | 89.9 (57.7) | 163 (70.6) | 398 (79.8) |
AUC12–24 (pg•h/mL) | 4.34 (250.5)b | 32.0 (147.0)d | 41.0 (91.3)e | 102 (100.9)f |
AUC0-tlast (pg•h/mL) | 30.7 (112.5) | 113 (74.4) | 196 (78.8) | 491 (84.4) |
AUC0-inf (pg•h/mL) | 66.2 (72.2)c | 127 (68.7)b | 252 (70.8)e | 598 (84.0)f |
Cmax (pg/mL) | 15.6 (72.0) | 27.3 (51.5) | 62.9 (72.3) | 160 (73.8) |
tmax a (h) | 0.333 (0.0330, 0.350) | 0.100 (0.0330, 0.383) | 0.100 (0.0330, 0.917) | 0.100 (0.0330, 0.933) |
t1/2 (h) | 5.09 (82.0)c | 6.28 (62.6)b | 8.76 (59.4)e | 9.61 (36.6)f |
CL/F (L/h) | 416 (77.0)c | 494 (89.6)b | 510 (81.3)e | 422 (75.6)f |
Vz/F (L) | 1995 (32.2)c | 3320 (56.9)b | 4627 (50.9)e | 4697 (49.7)f |