Figure 2

Glycoprotein synthesis in lung fibrosis. A) TNC, VCAN and FN gene expression in IPF (n = 17), cHP (n = 5), saHP (n = 4) and control lungs (n = 7). The bottom, middle band and top of the box are the first quartile, median and third quartile, respectively. TNC was significantly increased in IPF and cHP lungs compared with control (*p < 0.05) and saHP lungs (#p < 0.05). VCAN was higher in IPF and cHP compared with control lungs (*p < 0.05), and this increase was also significantly different in cHP compared with saHP lungs (#p < 0.05). No significant differences among groups were found in FN gene expression. B) Western-blotting showing an increase of TNC protein in IPF and cHP lungs compared with normal and saHP lungs. IPF: idiopathic pulmonary fibrosis, cHP: chronic hypersensitivity pneumonitis, saHP: subacute hypersensitivity pneumonitis, TNC: tenascin C, VCAN: versican, FN: fibronectin.