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Table 1 Characteristics of the study groups

From: Lung fibrotic tenascin-C upregulation is associated with other extracellular matrix proteins and induced by TGFβ1

 

Control

IPF

cHP

saHP

Number of subjects

7

17

5

4

Age (years)

40,2 ± 9,8*

62,5 ± 5

59,4 ± 8,2

53,5 ± 0,7*

Male/Female

5/2

12/5

4/1

2/2

Smoking (no/Ex/C)

4/1/2

6/9/2

2/2/1

1/3/0

FVC% pred

91,8 ± 2,4*

63,3 ± 14,2 #

73 ± 16,5

72 ± 9,9

DLCO% pred

90,4 ± 3,5*

43,7 ± 15 #

45,2 ± 18,5 #

48,4 ± 17,5

%FVC change

 

- 3,2 ± 6,2

- 1,9 ± 3,1

- 0,1 ± 2,1*

%DLCO change

 

- 2,9 ± 5,9

- 1,1 ± 3,5

+ 0,3 ± 4,5*

  1. Data are presented as mean ± SD. Results were analyzed using t-student test for parametric values or Mann–Whitney Rank Sum test for non-parametric values. *p < 0,05: significance difference compared with the IPF group; # p < 0,05: significance difference compared with the control group.
  2. No: never smoking; Ex: ex-smoker; C: current smoker; FVC: forced vital capacity; DLCO: diffusion lung capacity for carbon monoxide; IPF: idiopathic pulmonary fibrosis; cHP: chronic hypersensitivity pneumonitis; saHP: subacute hypersensitivity pneumonitis. %FVC change: Absolute change in percent-predicted FVC over 24 weeks. %DLCO change: Absolute change in percent-predicted DLCO over 24 weeks.