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Table 1 Seasonal variation of serum KL-6 concentrations in various interstitial lung diseases

From: Seasonal variation of serum KL-6 concentrations is greater in patients with hypersensitivity pneumonitis

 

Total

IPF

NSIP

CVD-IP

House-HP

Bird-HP

CPFE

Pvalue

n

96

16

16

33

9

9

13

-

Numbers of BAL/TBLB/SLB

55/50/18

4/4/0

14/13/8

20/17/2

8/7/5

9/9/3

0/0/0

-

Age

68 (11)

71 (14)

71 (12)

64 (10)*

71 (20)

71 (6)

70 (8)

0.007

Sex (Female)

41

3

9

23*

3

3

0#†

<0.001

No treatment

32

2

5

5

2

6*†

12*#†‡

<0.001

Duration of KL-6 measurement

903 (682)

1013 (670)

718 (326)

1097 (629)

569 (385)

605 (564)

819 (750)

0.072

Frequency of KL-6 measurement

15 (17)

13 (20)

16 (9)

22 (23)

17 (12)

11 (6)

9 (10)

0.133

Kmax

1264 (1182)

1620 (891)

1622 (1734)

993 (1002)

2157 (2162)

1761 (2110)

925 (384)#

0.004

Kmin

532 (349)

667 (335)

590 (328)

433 (287)*

451 (627)

489 (382)

483 (263)

0.070

Kmax-Kmin

686 (958)

793 (510)

1140 (1550)

633 (769)

1173 (1249)

1449 (1467)

360 (216)#§

0.001

Kmax/Kmin

2.46 (1.77)

2.09 (1.02)

3.06 (2.84)

2.47 (1.21)

3.98 (4.11)

4.13 (3.09)

1.95 (0.67)§

0.002

Smax

918 (769)

1231 (548)

1155 (1258)

885 (807)

1932 (1910)

847 (639)

770 (294)

0.090

Smin

588 (390)

696 (347)

715 (293)

438 (313)*

451 (615)

594 (549)

503 (290)

0.033

Smax-Smin

345 (580)

291 (856)

416 (1075)

406 (432)

1002 (1310)

236 (176)

174 (292)

0.072

Smax/Smin

1.61 (1.05)

1.49 (1.13)

1.54 (1.58)

1.76 (0.93)

3.68 (3.63)

1.31 (0.46)‡

1.35 (0.66)

0.047

Wmax

1105 (875)

1320 (799)

1148 (646)

878 (763)

649 (1756)

1572 (1008)†

905 (434)

0.012

Wmin

616 (413)

763 (581)

616 (276)

525 (328)*

491 (855)

750 (687)

551 (380)

0.073

Wmax-Wmin

392 (629)

327 (467)

495 (880)

259 (489)

252 (1120)

839 (721)†

342 (173)

0.051

Wmax/Wmin

1.65 (0.78)

1.46 (0.63)

1.80 (0.86)

1.44 (0.72)

1.47 (0.53)

2.78 (2.34)

1.82 (0.69)

0.078

Smax-Wmax

-51 (511)

-116 (581)

5 (632)

-17 (288)

353 (668)

-819 (609)#†‡

-179 (275)§

0.001

Smax/Wmax

0.93 (0.46)

0.88 (0.44)

1.01 (0.57)

0.96 (0.31)

1.43 (2.31)

0.47 (0.21)*#†‡

0.82 (0.30)‡§

<0.001

Smin-Wmin

-50 (181)

-135 (281)

22 (139)

-62 (114)

-42 (310)

-79 (197)

-54 (206)

0.066

Smin/Wmin

0.90 (0.27)

0.82 (0.27)

1.04 (0.21)

0.87 (0.21)

0.89 (0.20)

0.81 (0.31)

0.89 (0.26)

0.099

  1. The maximum and minimum concentrations of serum KL-6 throughout each patient’s clinical course was defined as Kmax and Kmin. Similarly, serum KL-6 concentrations during the summer (June 1 - September 30) were defined as Smax or Smin, and serum KL-6 concentrations during the winter (November 1 – February 28) as Wmax or Wmin. IPF, idiopathic pulmonary fibrosis; NSIP, non-specific interstitial pneumonia; CVD-IP, collagen vascular disease-related interstitial pneumonia; House-HP, house-related hypersensitivity pneumonitis; Bird-HP, bird-related hypersensitivity pneumonitis; CPFE, combined pulmonary fibrosis and emphysema; BAL, bronchoalveolar lavage; TBLB, transbronchial lung biopsy; SLB, surgical lung biopsy. Data are expressed as the median (interquartile range).
  2. *P < 0.0033 vs IPF.
  3. #P <0.0033 vs NSIP.
  4. †P < 0.0033 vs CVD-IP.
  5. ‡P <0.0033 vs House-HP.
  6. §P <0.0033 vs Bird-HP.
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BMC Pulmonary Medicine

ISSN: 1471-2466

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