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Table 2 Performances of the Xpert®MTB/RIF assay, smear microscopy, and culture using FOB samples for the diagnosis of pulmonary tuberculosis

From: Retrospective observational study of diagnostic accuracy of the Xpert® MTB/RIF assay on fiberoptic bronchoscopy sampling for early diagnosis of smear-negative or sputum-scarce patients with suspected tuberculosis

 

Performances relative to culture

Performances relative to final diagnosis

 

Sensitivity%

Specificity%

Sensitivity%

Specificity%

 

(95% CI) n

(95% CI) n

(95% CI) n

(95% CI) n

Xpert® MTB/RIF assay

80.0

98.6

60.0

100.0

(57.8-92.5)

(94.7-99.9)

(42.3-75.4)

(96.6-100.0)

16/20

140/142

18/30

132/132

Smear microscopy

25.0

95.8

16.7

95.5

(10.8-47.3)

(90.9-98.3)

(6.9-34.0)

(90.2-98.1)

5/20

136/142

5/30

126/132

Culture

-

-

66.7

100.0

(48.7-80.9)

(96.6-100.0)

20/30

132/132

p-valuea

0.003

0.288

0.001 b

0.041 b

0.683 c

-

   

0.0003 d

0.041 d

  1. a p-values were calculated using the McNemar’s test.
  2. b p-value between Xpert®MTB/RIFassay vs. smear microscopy.
  3. c p-value between Xpert®MTB/RIFassay vs. culture.
  4. d p-value between culture vs. smear microscopy.