Determinants of outcome of solitary fibrous tumors of the pleura: an observational cohort study

Table 3 Investigated variables with a possible impact on the outcome of patients with solitary fibrous tumors of the pleura

Variable	HR	CI	p-value*
Univariate analysis
Gender	0.54	0.89-3.26	ns
Age	1.13	0.91-1.30	ns
History of smoking	2.26	0.29-2.35	ns
Symptomatic SFTP	1.19	0.20-7.14	ns
Inhomogeneous appearance on CT	4.69	0.48-45.52	ns
Sessile SFTP	3.90	0.43-35.04	ns
Necrosis or hemorrhage	0.14	0.02-1.31	ns
Atypical localization	0.04	0.03-4.3	ns
Malignant SFTP according to Okike classification [2]	0.21	0.02-2.00	ns
Pleomorphism	0.45	0.07-2.74	ns
Desmin	2.35	0.43-5.34	ns
Vimentin	3.65	0.33-40.32	ns
CD 34	1.0	0.8-2.2	ns
CD 99	4.84	0.44-53.81	ns
Bcl-2	5.32	0.87-7.34	ns
SMA	2.29	0.03-8.54	ns
Tumor diameter ≥ 10 cm	1.24	1.04-1.47	0.015**
≥ 10 mitotic figures/10 HPF	1.33	1.08-1.63	0.008**
Proliferation rate ≥ 12%***	1.09	1.02-1.16	0.015**
Multivariate analysis
Tumor diameter ≥ 10 cm	12.45	0.28-5578.61	ns
≥ 10 mitotic figures/10 HPF	2.29	0.29-18.12	ns
Proliferation rate ≥ 12%***	1.53	0.35-6.64	ns

*Cox regression analysis; **Variables with a p-value ≤ 0.05 were entered into the multivariate analysis; ***Determined by Ki-67 expression (MIB-1 labeling index); HR, hazard ratio; CI, confidence interval; CT, computed tomography; ns, not significant; HPF, high-power field, SFTP, solitary fibrous tumor of the pleura; SMA, smooth muscle antigen; bcl-2, B-cell lymphoma 2 protein.