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Table 4 Genotype frequencies of selected SNPS with significant differences in children with recurrent or non-recurrent wheezing a

From: Genetic polymorphisms and risk of recurrent wheezing in pediatric age

 

Observed

Expected

     

Gene and polymorphic alleles

Non-recurrent (n = 74)

Recurrent wheezing (n = 45)

Non-recurrent (n = 74)

Recurrent wheezing (n = 45)

HWE, χ 2non-recurrent

HWE, χ 2recurrent

   
 

N

%

N

%

N

%

N

%

p-value

p-value

ORb

95% CI

p-valuec

IL8-rs4073

             

A

17

23.3

4

8.9

12.3

16.9

8.5

18.8

  

1.00

(Reference)

-

A/T

26

35.6

31

68.9

35.3

48.4

22.1

49.1

  

3.60

(1.03-12.57)

0.04

T

30

41.1

10

22.2

25.3

34.7

14.5

32.1

0.02

0.007

1.18

(0.31-4.51)

0.81

VEGFA-rs2146323

             

A

4

5.4

8

17.8

6.8

9.2

6.8

15.1

  

4.32

(1.06-17.64)

0.04

A/C

37

50.0

19

42.2

31.3

42.3

21.4

47.5

  

1.08

(0.46-2.54)

0.85

C

33

44.6

18

40.0

35.8

48.4

16.8

37.3

0.12

0.45

1.00

(Reference)

-

TLR3-rs3775291

             

T

10

13.7

4

8.9

8.9

12.2

2.5

5.4

  

0.75

(0.20-2.75)

0.66

T/C

31

42.5

13

28.9

33.2

45.5

16.1

35.8

  

0.36

(0.14-0.90)

0.03

C

32

43.8

28

62.2

30.9

42.3

26.5

58.8

0.57

0.20

1.00

(Reference)

-

NFKBIA-rs2233419

             

A

5

6.8

2

4.4

1.9

2.6

2.2

4.9

  

0.82

(0.13-5.05)

0.83

A/G

14

18.9

16

35.6

20.1

27.2

15.6

34.6

  

2.79

(1.12-6.99)

0.03

G

55

74.3

27

60.0

51.9

70.2

27.2

60.5

0.009

0.85

1.00

(Reference)

-

  1. aThe sums may not add up to the total because of a few missing values; bOdds ratios adjusted for age (< / ≥ 2 years). cp-values from univariate analyses, not adjusted for multiple testing. None of the p-values was significant after correction for multiple testing. HWE Hardy-Weinberg equilibrium.
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BMC Pulmonary Medicine

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