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Table 4 Genotype frequencies of selected SNPS with significant differences in children with recurrent or non-recurrent wheezing a

From: Genetic polymorphisms and risk of recurrent wheezing in pediatric age

  Observed Expected      
Gene and polymorphic alleles Non-recurrent (n = 74) Recurrent wheezing (n = 45) Non-recurrent (n = 74) Recurrent wheezing (n = 45) HWE, χ 2non-recurrent HWE, χ 2recurrent    
  N % N % N % N % p-value p-value ORb 95% CI p-valuec
IL8-rs4073              
A 17 23.3 4 8.9 12.3 16.9 8.5 18.8    1.00 (Reference) -
A/T 26 35.6 31 68.9 35.3 48.4 22.1 49.1    3.60 (1.03-12.57) 0.04
T 30 41.1 10 22.2 25.3 34.7 14.5 32.1 0.02 0.007 1.18 (0.31-4.51) 0.81
VEGFA-rs2146323              
A 4 5.4 8 17.8 6.8 9.2 6.8 15.1    4.32 (1.06-17.64) 0.04
A/C 37 50.0 19 42.2 31.3 42.3 21.4 47.5    1.08 (0.46-2.54) 0.85
C 33 44.6 18 40.0 35.8 48.4 16.8 37.3 0.12 0.45 1.00 (Reference) -
TLR3-rs3775291              
T 10 13.7 4 8.9 8.9 12.2 2.5 5.4    0.75 (0.20-2.75) 0.66
T/C 31 42.5 13 28.9 33.2 45.5 16.1 35.8    0.36 (0.14-0.90) 0.03
C 32 43.8 28 62.2 30.9 42.3 26.5 58.8 0.57 0.20 1.00 (Reference) -
NFKBIA-rs2233419              
A 5 6.8 2 4.4 1.9 2.6 2.2 4.9    0.82 (0.13-5.05) 0.83
A/G 14 18.9 16 35.6 20.1 27.2 15.6 34.6    2.79 (1.12-6.99) 0.03
G 55 74.3 27 60.0 51.9 70.2 27.2 60.5 0.009 0.85 1.00 (Reference) -
  1. aThe sums may not add up to the total because of a few missing values; bOdds ratios adjusted for age (< / ≥ 2 years). cp-values from univariate analyses, not adjusted for multiple testing. None of the p-values was significant after correction for multiple testing. HWE Hardy-Weinberg equilibrium.