From: Non-emphysematous chronic obstructive pulmonary disease is associated with diabetes mellitus
Characteristic or comorbidity | Definition | COPDGene reference, if applicable |
---|---|---|
Asthma-COPD overlap | Self-report of physician diagnosis of asthma before age 40 | Hardin 2011 [29] |
Hypoxemia | Resting oxygen saturation ≤88% | Kim 2011 [30] |
Frequent exacerbator | 2 or more exacerbations requiring antibiotics and/or systemic steroids in the year prior to enrollment | Han 2011 [33] |
Severe, early-onset COPD | Age < 55 years, FEV1 < 50% predicted | Foreman 2011 [34] |
Poor exercise capacity | 6-minute walk distance <500 feet | Rambod 2012 [32] |
Bronchodilator response | Increase in FEV1 200Â ml and 12% from baseline | Â |
Pink puffer | Emphysema > 10%, BMI ≤ 20, O2 sat ≥ 90% |  |
Blue bloater | Chronic bronchitis, BMI > 25, O2 sat < 90% |  |
Chronic bronchitis | Chronic cough and phlegm for ≥3 mo/yr for at least 2 consecutive years | Kim 2011 [31] |
Chronic prednisone use | Self-report | Swift 2012 [35] |
Cardiovascular disease | Self-report of heart attack, coronary artery disease, angina, angioplasty, coronary artery bypass graft, congestive heart failure, peripheral vascular disease, transient ischemic attack or stroke | Black-Shinn 2014 [36] |
Coronary disease | Self-report of heart attack, coronary artery disease, angina, angioplasty, or coronary artery bypass graft | Â |
Congestive heart failure | Self-report | Â |
Peripheral vascular disease | Self-report | Â |
Cerebrovascular disease | Self-report of transient ischemic attack or stroke | Â |
Sleep apnea | Self-report | Â |
Diabetes mellitus | Self-report | Kinney 2014 [37] |
Metabolic syndrome | 3 of 4: BMI > 30 (measured), diabetes mellitus, hypertension, and high cholesterol (all self-report) |  |
Gastroesophageal reflux disease | Self-report | Â |
Peptic ulcer disease | Self-report | Â |
Osteoporosis | Self-report | Â |