Skip to main content

Table 2 Demographic and clinical attributes of subjects with non-emphysematous and emphysema-predominant COPD (GOLD 1–4)

From: Non-emphysematous chronic obstructive pulmonary disease is associated with diabetes mellitus

 

No/minimal emphysema

Emphysema-predominant

p-value

N

1817

1687

 

Age

60.6 (±8.8)

65.6 (±7.7)

<0.0001

Male sex

933 (51.3%)

1000 (59.3%)

<0.0001

African American race

479 (26.4%)

288 (17.1%)

<0.0001

Pack-years of smoking

47.3 (±24.4)

55.9 (±28.1)

<0.0001

Current smoking

1122 (61.8%)

392 (23.2%)

<0.0001

Body Mass Index, kg/m2

29.3 (±6.3)

25.9 (±5.2)

<0.0001

Forced Expiratory Volume in 1 s (FEV1), % predicted

68.4 (±18.4)

44.5 (±21.0)

<0.0001

GOLD Stage

   

1

487 (26.8%)

121 (7.2%)

 

2

1025 (56.4%)

453 (26.9%)

 

3

267 (14.7%)

649 (38.5%)

 

4

38 (2.1%)

464 (27.5%)

 

FEV1 / Forced Vital Capacity ratio

0.61 (±0.08)

0.42 (±0.12)

<0.0001

Bronchodilator response, change in FEV1, % of baseline

7.2 (±11.7)

9.1 (±12.6)

<0.0001

Bronchodilator response, change in FEV1, L

0.11 (±0.19)

0.09 (±0.13)

0.001

Bronchodilator response, % of predicted FEV1

3.8 (±6.4)

3.2 (±4.5)

0.002

6-minute walk distance, ft.

1331 (±383)

1138 (±403)

<0.0001

Oxygen saturation by pulse oximetry, %

95.9 (±2.8)

94.0 (±3.9)

<0.0001

Modified Medical Research Council dyspnea score

1.5 (±1.5)

2.4 (±1.3)

<0.0001

St. George’s Respiratory Questionnaire total score

30.7 (±22.9)

43.0 (±20.6)

<0.0001

BODE index*

1.6 (±1.7)

3.6 (±2.1)

<0.0001

Emphysema at -950 Hounsfield units, %

2.0 (±1.4)

23.6 (±10.7)

<0.0001

Square root wall area of an airway with 10 mm internal perimeter

3.71 (±0.15)

3.70 (±0.13)

0.001

Wall area % of segmental airways

62.7 (±3.4)

62.2 (±3.0)

<0.0001

  1. *BODE = Body mass, airflow Obstruction, Dyspnea, Exercise capacity [38].
  2. Mean (±SD) or N (%) are shown.