Figure 5From: The effect of the novel phosphodiesterase-4 inhibitor MEM 1414 on the allergen induced responses in mild asthma TNFα release in stimulated whole blood. (A) MEM 1414 concentration response curve baseline assessment for TNFα release in whole blood. Blood was stimulated with 1 μM LPS. *p < 0.05 ANOVA. (B) TNFα release in whole blood during treatment periods. Data shows change in ECmax TNFα release from pre allergen challenge compared to 3, 8 and 24 hours post allergen challenge. *p = 0.038 ANOVA. Data are mean ± S.D. AC: allergen challenge.Back to article page