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Figure 1 | BMC Pulmonary Medicine

Figure 1

From: Upregulation of activin-B and follistatin in pulmonary fibrosis – a translational study using human biopsies and a specific inhibitor in mouse fibrosis models

Figure 1

INHBB and follistatin mRNA expression is increased in IPF lung. A. The mRNA expression levels of TGF-ß/BMP pathway genes in human idiopathic pulmonary fibrosis (IPF) lung (N = 4) and control lung (N = 4) were measured using a PCR array. In the scatter plot, IPF group is plotted against the control group. At least threefold differences in mRNA expression levels are indicated with green (upregulation) and red (downregulation) color. INHBB and follistatin mRNA expression was increased 3.8-fold and 3.6-fold, respectively. Col, collagen; LTBP1, latent TGF-ß binding protein; IGF, insulin-like growth factor; IGFBP, IGF binding protein; BMP, bone morphogenetic protein. B. INHBB and FST mRNA expression levels were confirmed by quantitative RT-PCR.

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BMC Pulmonary Medicine

ISSN: 1471-2466

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