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Figure 4 | BMC Pulmonary Medicine

Figure 4

From: Upregulation of activin-B and follistatin in pulmonary fibrosis – a translational study using human biopsies and a specific inhibitor in mouse fibrosis models

Figure 4

Effect of activin inhibition to mouse body composition after particulate exposure. A. Effect of activin inhibition using sActRIIB-Fc on body mass of mice exposed oropharyngeally to either asbestos or silica dust. E1 and E2 show time points of dust exposure. B. Effect of activin inhibition on skeletal muscle mass. In asbestos-exposed animals, 5 animals with equal starting mass were chosen for measurement. In silica-exposed animals N = 9 and in controls N = 6. C. Epididymal and retroperitoneal fat masses of mice treated with sActRIIB-Fc and exposed to either asbestos (Asb, A; N = 5/group) or silica (B; N = 9 in the exposed animal groups and N = 5 in the control (Ctrl) group).

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BMC Pulmonary Medicine

ISSN: 1471-2466

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