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Table 2 IC 50 values for cisplatin in NSCLC lines with or without GC7 treatment after eIF5A-2 inhibition

From: Cisplatin sensitivity is enhanced in non-small cell lung cancer cells by regulating epithelial-mesenchymal transition through inhibition of eukaryotic translation initiation factor 5A2

NSCLC cell line

IC50(μg/mL)▲

 

siRNA + Cisplatin

siRNA + Cisplatin + GC7 (20 μM)

A549

2.626 (2.466–2.785)

2.434 (2.307–2.560)

NCI-H1299

4.468 (4.093–4.842)

3.982 (3.609–4.356)

  1. ▲IC50 values indicate the cisplatin concentration [μg/mL; mean (95% CI)].
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BMC Pulmonary Medicine

ISSN: 1471-2466

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