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Table 2 Comparison of analysers and methods reflecting the opinions of the multidisciplinary specialist PCD team having conducted the research

From: Validation of a portable nitric oxide analyzer for screening in primary ciliary dyskinesias

  NIOX® Flex 20 seconds NIOX MINO®
Ease of use Easily used by children over 8 years and by some younger using breath hold (BH) Breath hold difficult for 45 sec/ 90 sec by all ages. Tidal breathing (TB) easily achieved in 5 ml/sec sampling mode
Time to complete 3 readings 5-10 min (BH) 20-40 min (TB)
Practical issues Needs stable environment and dedicated work space. Needs to be used on a flat surface
  Poor portability Excellent portability
  Breath-holding technique difficult for young children and advanced lung disease Most people could manage the technique but it resulted in a dry mouth. Short sampling catheter
Cost of machine Very Expensive. Approx £30,000 Expensive. Approx £2,100
Need for calibration gases Yes. Approx £1,500 per annum No- autocalibrates
Need for maintenance service Yes. Approx £3,800 per annum No
Consumables Nasal sampling olives: £40 per 100 Nasal sampling olives: £40 per 100 patients
Longevity Good Sensor needs replacing after 100 or 300 readings (using our protocol 30 or 100 patients). Many readings failed but were still ‘counted’. Sensor expires after 1 year Approx. £1,215 for sensor 300.
Range of nNO (ppb) 25-2000 ppb 5-1700 ppb
Effected by other electronic devices in room e.g. mobile phones No Yes