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Table 4 Comparisons of pro-inflammatory and anti-inflammatory cytokines in BALF and blood between pure PJP patients with PaO 2 /FiO 2 ≤ 200 and >200 mmHg

From: The impact of concomitant pulmonary infection on immune dysregulation in Pneumocystis jirovecii pneumonia

 

PaO2/FiO2>200 mmHg(N =24)

PaO2/FiO2 ≤ 200 mmHg(N =9)

P value*

P value#

BALF

    

  IL-1β, pg/ml

2.24(1.85;2.86)

2.65(2.00;5.32)

0.414

 

  TNF-α, pg/ml

10.09(7.82;12.44)

13.08(9.52;17.82)

0.154

 

  IL-8, pg/ml

48.40(24.38;168.25)

175.30(35.00;342.90)

0.193

 

  IL-17, pg/ml

15.00(15.00;15.00)

15.00(15.00;15.00)

0.645

 

  MCP-1, pg/ml

1066.50(663.37;2593.31)

2453.16(715.00;4288.47)

0.254

 

  IL-10, pg/ml

4.25(3.90;8.93)

3.90(3.90;8.12)

0.414

 

  TGF-β1, pg/ml

53.40(45.45;128.30)

43.90(42.10;51.70)

0.150

 

  IL-1RA, pg/ml

709.70(463.30;1730.20)

1835.20(929.33;2816.00)

0.045

0.144

  IL-1β/IL-10

0.41(0.29;0.57)

0.54(0.40;1.36)

0.238

 

  TNF-α/IL-10

2.33(1.19;2.63)

2.44(2.06;3.50)

0.179

 

  IL-8/IL-10

8.83(3.67;32.04)

28.22(8.78;53.10)

0.166

 

  IL-17/IL-10

3.85(2.84;3.85)

3.85(2.42;3.85)

0.547

 

  MCP-1/ IL-10

220.15(110.95;334.84)

629.02(170.28;914.57)

0.131

 

  IL-1β/TGF-β1

0.03(0.01;0.05)

0.06(0.03;0.13)

0.026

0.741

  TNF-α/TGF-β1

0.16(0.03;0.22)

0.23(0.22;0.37)

0.003

0.421

  IL-8/TGF-β1

0.63(0.16;1.84)

3.26(0.80;7.94)

0.032

0.787

  IL-17/TGF-β1

0.29(0.27;0.33)

0.36(0.29;0.38)

0.121

 

  MCP-1/TGF-β1

14.13(4.40;34.32)

58.27(13.32;107.14)

0.032

0.158

  IL-1β/IL-1RA

0.00(0.00;0.01)

0.00(0.00;0.00)

0.210

 

  TNF-α/IL-1RA

0.02(0.01;0.04)

0.01(0.00;0.01)

0.121

 

  IL-8/IL-1RA

0.18(0.02;0.99)

0.07(0.02;0.12)

0.374

 

  IL-17/IL-1RA

0.02(0.01;0.03)

0.01(0.01;0.02)

0.140

 

  MCP-1/IL-1RA

0.99(0.24;4.05)

1.48(0.46;1.52)

0.750

 

Blood

    

  TNF-α, pg/ml

14.50(10.60;17.50)

12.70(8.50;24.20)

0.640

 

  IL-8, pg/ml

33.81(18.85;78.35)

41.20(21.60;90.55)

0.766

 

  IL-17, pg/ml

15.00(15.00;15.00)

15.00(15.00;15.00)

0.643

 

  MCP-1, pg/ml

1557.80(792.83;2655.05)

1382.60(318.75;2337.80)

0.512

 

  IL-10, pg/ml

33.40(12.25;56.93)

20.80(9.65;32.95)

0.111

 

  TGF-β1, pg/ml

255.15(168.10;3908.20)

3479.90(1020.85;10050.65)

0.014

0.892

  IL-1RA, pg/ml

1087.90(297.10;2697.80)

701.80(286.90;2375.60)

0.938

 

  IL-8/IL-10

1.22(0.59;1.76)

2.79(1.14;4.14)

0.020

0.903

  IL-8/TGF-β1

0.12(0.04;0.48)

0.02(0.01;0.04)

0.020

0.787

  TNF-α/IL-10

0.35(0.17;0.93)

0.72(0.43;1.34)

0.035

0.872

  TNF-α/TGF-β1

0.07(0.02;0.24)

0.00(0.00;0.03)

0.012

0.233

  1. Data are expressed as median IQR (25%;75%).
  2. PaO2/FiO2 = arterial oxygen tension/fraction of inspired oxygen; BALF = Bronchoalveolar lavage fluid; PJP = Pneumocystis jirovecii pneumonia; IL = Interleukin; TGF-β1 = Transforming growth factor-β1; TNF-α = Tumor necrosis factor-α; MCP-1 = Monocyte chemoattractant protein-1; IL-1RA = IL-1 receptor antagonist.
  3. The comparison was made by Mann–Whitney U test.
  4. P*: univariate analysis, P#: multivariate analysis.