Table 5 Comparisons of pro-inflammatory and anti-inflammatory cytokines in BALF and blood between pure PJP patients with and without ventilator
Without ventilator (N =22) | With ventilator (N =25) | P value* | P value# | |
|---|---|---|---|---|
BALF | ||||
IL-1β, pg/ml | 2.23(1.73;2.91) | 2.10(1.53;3.46) | 0.915 | |
TNF-α, pg/ml | 9.81(7.23;14.31) | 10.30(9.09;12.84) | 0.332 | |
IL-8, pg/ml | 35.63(22.28;70.59) | 59.90(32.95;249.65) | 0.023 | 0.043 |
IL-17, pg/ml | 15.00(15.00;15.00) | 15.00(15.00;15.00) | 0.876 | |
MCP-1, pg/ml | 847.20(114.46;3158.55) | 1048.50(326.90;2761.43) | 0.565 | |
IL-10, pg/ml | 5.33(3.90;9.25) | 3.90(3.90;5.50) | 0.049 | 0.954 |
TGF-β1, pg/ml | 53.40(42.10;707.20) | 48.80(42.10;55.10) | 0.203 | |
IL-1RA, pg/ml | 1323.10(566.70;3432.50) | 1142.20(632.70;2303.10) | 0.678 | |
IL-1β/IL-10 | 0.39(0.26;0.55) | 0.49(0.37;0.57) | 0.119 | |
TNF-α/IL-10 | 2.23(1.11;2.58) | 2.51(2.06;2.71) | 0.098 | |
IL-8/IL-10 | 7.24(3.31;12.42) | 15.36(8.26;48.67) | 0.004 | 0.733 |
IL-17/IL-10 | 3.85(3.12;3.85) | 3.85(2.84;3.85) | 0.981 | |
MCP-1/ IL-10 | 103.17(28.60;402.18) | 262.10(74.72;397.89) | 0.172 | |
IL-1β/TGF-β1 | 0.03(0.00;0.05) | 0.04(0.03;0.07) | 0.018 | 0.545 |
TNF-α/TGF-β1 | 0.13(0.01;0.25) | 0.21(0.18;0.26) | 0.017 | 0.321 |
IL-8/TGF-β1 | 0.47(0.07;1.02) | 1.35(0.73;5.61) | <0.001 | 0.707 |
IL-17/TGF-β1 | 0.29(0.08;0.46) | 0.31(0.27;0.36) | 0.793 | |
MCP-1/TGF-β1 | 5.13(0.50;36.72) | 21.51(5.32;56.99) | 0.023 | 0.369 |
IL-1β/IL-1RA | 0.00(0.00;0.01) | 0.00(0.00;0.00) | 0.649 | |
TNF-α/IL-1RA | 0.01(0.00;0.02) | 0.01(0.00;0.02) | 0.756 | |
IL-8/IL-1RA | 0.03(0.01;0.08) | 0.10(0.02;0.40) | 0.126 | |
IL-17/IL-1RA | 0.02(0.00;0.03) | 0.01(0.01;0.03) | 0.943 | |
MCP-1/IL-1RA | 0.24(0.03;0.70) | 1.47(0.28;1.85) | 0.011 | 0.582 |
Blood | ||||
TNF-α, pg/ml | 9.90(8.30;17.10) | 12.45(10.20;17.15) | 0.123 | |
IL-8, pg/ml | 22.30(14.23;40.75) | 42.70(22.95;105.15) | 0.004 | 0.969 |
IL-17, pg/ml | 15.00(15.00;15.00) | 15.00(15.00;15.00) | 0.866 | |
MCP-1, pg/ml | 931.65(368.58;1719.33) | 1382.60(459.80;2485.55) | 0.354 | |
IL-10, pg/ml | 11.21(9.33;21.60) | 32.90(13.35;47.25) | 0.006 | 0.938 |
TGF-β1, pg/ml | 260.35(225.00;11506.09) | 557.50(269.85;5782.80) | 0.898 | |
IL-1RA, pg/ml | 2114.30(693.50;3696.90) | 701.80(286.90;2117.70) | 0.169 | |
IL-8/IL-10 | 1.83(0.80;2.61) | 1.71(0.94;2.81) | 0.966 | |
IL-8/TGF-β1 | 0.04(0.00;0.15) | 0.10(0.01;0.23) | 0.159 | |
TNF-α/IL-10 | 1.10(0.65;1.31) | 0.45(0.25;0.74) | 0.022 | 0.160 |
TNF-α/TGF-β1 | 0.00(0.00;1.80) | 0.03(0.00;0.07) | 0.540 |