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Table 2 List of 30 replicated emphysema genes

From: Genes related to emphysema are enriched for ubiquitination pathways

mRNA

Gene symbol

Gene name

Discovery slope

Discovery slope P value*

Replication slope

Replication slope P value

NM_005706

TSSC4

Tumor suppressing subtransferable candidate 4

-0.00037

0.039

-0.00096

0.003

AB067498

Esco1

Establishment of cohesion 1 homolog 1 (S. cerevisiae)

0.00038

0.018

0.00045

0.005

NM_018559

kiaa1704

KIAA1704

0.00040

0.023

0.00065

0.006

NM_004897

MINPP1

Multiple inositol polyphosphate histidine phosphatase, 1

0.00035

0.033

0.00070

0.006

Contig55580_RC

  

0.00049

0.029

0.00139

0.006

NM_012180

FBXO8

F-box protein 8

0.00040

0.010

0.00067

0.014

NM_153044

MORC2-AS1

MORC2 antisense RNA 1

-0.00040

0.022

-0.00054

0.015

NM_022876

SMN2

Survival of motor neuron 2, centromeric

0.00046

0.019

0.00083

0.017

NM_003838

FPGT

Fucose-1-phosphate guanylyltransferase

0.00035

0.031

0.00054

0.018

AF055030

PHF10

PHD finger protein 10

0.00036

0.011

0.00067

0.019

NM_007342

NUPL2

Nucleoporin like 2

0.00037

0.047

0.00081

0.019

Contig45624_RC

CBLL1

Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase

0.00052

0.018

0.00091

0.020

NM_002103

GYS1

Glycogen synthase 1 (muscle)

-0.00033

0.017

-0.00052

0.020

AL359938

MEIS3

Meis homeobox 3; Meis homeobox 3 pseudogene 2

-0.00029

0.040

-0.00054

0.022

NM_014771

RNF40

Ring finger protein 40

-0.00034

0.027

-0.00067

0.024

NM_022877

SMN2

Survival of motor neuron 2, centromeric

0.00046

0.018

0.00077

0.024

Contig41498_RC

PTPN4

Protein tyrosine phosphatase, non-receptor type 4

0.00035

0.027

0.00049

0.024

NM_003084

SNAPC3

Small nuclear RNA activating complex, polypeptide 3

0.00044

0.015

0.00075

0.025

NM_013234

EIF3K

Eukaryotic translation initiation factor 3, subunit K

-0.00025

0.044

-0.00045

0.027

NM_006852

TLK2

Tousled-like kinase 2

0.00021

0.037

0.00032

0.028

X68560

SP3

Sp3 transcription factor

0.00065

0.012

0.00113

0.030

AY007149

CEP350

Centrosomal protein 350 kDa

0.00034

0.029

0.00058

0.030

Contig51940_RC

GABPA

GA binding protein transcription factor, alpha subunit 60 kDa

0.00046

0.035

0.00093

0.033

NM_032557

USP38

Ubiquitin specific peptidase 38

0.00048

0.017

0.00073

0.034

NM_015153

PHF3

PHD finger protein 3

0.00060

0.034

0.00057

0.036

NM_004162

RAB5A

RAB5A, member RAS oncogene family

0.00030

0.045

0.00048

0.037

NM_022875

SMN2

Survival of motor neuron 2, centromeric

0.0004843

0.015

0.00071

0.039

NM_005316

GTF2H1

General transcription factor IIH, polypeptide 1, 62 kDa

0.00042

0.010

0.00069

0.039

Contig53191_RC

GPD2

Glycerol-3-phosphate dehydrogenase 2 (mitochondrial)

0.00043

0.043

0.00069

0.041

NM_017411

SMN2

Survival of motor neuron 2, centromeric

0.00048

0.029

0.00071

0.044

  1. *All FDR values were >0.1 in the discovery samples.
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BMC Pulmonary Medicine

ISSN: 1471-2466

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