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Figure 4 | BMC Pulmonary Medicine

Figure 4

From: Distinct compartmentalization of SP-A and SP-D in the vasculature and lungs of patients with idiopathic pulmonary fibrosis

Figure 4

Immunohistochemistry of control lung tissue and lung biopsies from idiopathic pulmonary fibrosis (IPF) patients. (A-B) In normal tissue, the cytoplasm of type II alveolar epithelial cells was positive for (A) SP-A (brown) and (B) SP-D (brown). (C-D) In IPF lungs, the type II alveolar epithelial cells were hyperplastic, and strongly positive for (C) SP-A (brown) and (D) SP-D (brown). (E-F) The thick mucus inside honeycomb cysts and ectatic respiratory tracts was highly immunoreactive for (E) SP-A but not for (F) SP-D. (G-H) Inside blood vessels (arrows) were often positive for (h) SP-D but not for (g) SP-A.

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BMC Pulmonary Medicine

ISSN: 1471-2466

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