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Table 1 Patient characteristics and the data of serum and BALF levels of SP-A and SP-D

From: Distinct compartmentalization of SP-A and SP-D in the vasculature and lungs of patients with idiopathic pulmonary fibrosis

 

IPF

SAR

HS

 

N

36

18

20

 

Sex (male: female)

18:8

8:10 P = 0.073

17:3 P = 0.339

P = 0.004

Age (years old)

67.6 ± 8.0

53.7 ± 16.2 P < 0.001

28.2 ± 6.3 P < 0.001

P < 0.001

Smoking status (current: ex-: never smoker)

7: 20: 9

4: 8: 6 P = 0.528

8: 0: 12 P < 0.001

P < 0.001

BALF recovery (%)

51.7 ± 16.5

57.9 ± 12.5 P = 0.513

66.1 ± 22.4 P = 0.001

P = 0.002

Serum SP-A level (ng/ml)

84.5 (55.5 – 115.8)

33.3 (26.1 – 52.0) P < 0.001

-

 

Serum SP-D level (ng/ml)

272.0 (172.0 – 441.8)

75.0 (48.8 – 97.3) P < 0.001

-

 

BALF SP-A level (ng/ml)

1275.0 (581.0 – 2672.5)

1600.0 (972.0 – 3220.0)

1978.0 (1380.0 – 3749.0)

P = 0.245

BALF SP-D level (ng/ml)

379.0 (223.8 – 570.8)

704.5 (389.3 – 967.5) P = 0.003

667.0 (391.0 – 1219.0) P = 0.003

P < 0.001

BALF/serum ratio of SP-A levels

19.1 (6.9 – 41.6)

51.2 (18.5 – 103.8) P = 0.01

-

 

BALF/serum ratio of SP-D levels

1.3 (0.7 – 2.4)

7.8 (4.7 – 20.1) P < 0.001

-

 
  1. The data of age and the BALF recovery rate with symmetric distribution are presented as mean ± standard deviation. Sex and the smoking status were evaluated by the chi-square test. The other data show asymmetric distribution, which is presented as a median (interquartile range). P values below each data value were calculated using the Mann–Whitney U–test to compare with the IPF group. P values in the rightmost column were calculated using the Kruskal–Wallis test to analyze the distribution of data among the three groups. SP-A, surfactant protein A; SP-D, surfactant protein D; BALF, bronchoalveolar lavage fluid; HS, healthy subjects; IPF, idiopathic pulmonary fibrosis patients; SAR, sarcoidosis patients.