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Table 1 Patient characteristics and the data of serum and BALF levels of SP-A and SP-D

From: Distinct compartmentalization of SP-A and SP-D in the vasculature and lungs of patients with idiopathic pulmonary fibrosis

  IPF SAR HS  
N 36 18 20  
Sex (male: female) 18:8 8:10 P = 0.073 17:3 P = 0.339 P = 0.004
Age (years old) 67.6 ± 8.0 53.7 ± 16.2 P < 0.001 28.2 ± 6.3 P < 0.001 P < 0.001
Smoking status (current: ex-: never smoker) 7: 20: 9 4: 8: 6 P = 0.528 8: 0: 12 P < 0.001 P < 0.001
BALF recovery (%) 51.7 ± 16.5 57.9 ± 12.5 P = 0.513 66.1 ± 22.4 P = 0.001 P = 0.002
Serum SP-A level (ng/ml) 84.5 (55.5 – 115.8) 33.3 (26.1 – 52.0) P < 0.001 -  
Serum SP-D level (ng/ml) 272.0 (172.0 – 441.8) 75.0 (48.8 – 97.3) P < 0.001 -  
BALF SP-A level (ng/ml) 1275.0 (581.0 – 2672.5) 1600.0 (972.0 – 3220.0) 1978.0 (1380.0 – 3749.0) P = 0.245
BALF SP-D level (ng/ml) 379.0 (223.8 – 570.8) 704.5 (389.3 – 967.5) P = 0.003 667.0 (391.0 – 1219.0) P = 0.003 P < 0.001
BALF/serum ratio of SP-A levels 19.1 (6.9 – 41.6) 51.2 (18.5 – 103.8) P = 0.01 -  
BALF/serum ratio of SP-D levels 1.3 (0.7 – 2.4) 7.8 (4.7 – 20.1) P < 0.001 -  
  1. The data of age and the BALF recovery rate with symmetric distribution are presented as mean ± standard deviation. Sex and the smoking status were evaluated by the chi-square test. The other data show asymmetric distribution, which is presented as a median (interquartile range). P values below each data value were calculated using the Mann–Whitney U–test to compare with the IPF group. P values in the rightmost column were calculated using the Kruskal–Wallis test to analyze the distribution of data among the three groups. SP-A, surfactant protein A; SP-D, surfactant protein D; BALF, bronchoalveolar lavage fluid; HS, healthy subjects; IPF, idiopathic pulmonary fibrosis patients; SAR, sarcoidosis patients.