Patient disposition and CONSORT flow chart. *1 patient each in UMEC 15.6 μg QD (acute respiratory failure), UMEC 31.25 μg QD (myocardial infarction), and UMEC 31.25 μg BID (dizziness) during active treatment. †1patient in UMEC 125 μg QD (nasopharyngitis) during washout. Number of patients (N) for completed treatment period, withdrawn during treatment period, and withdrawn during washout period reflects the total number of patients in each treatment group across all three treatment periods who completed the treatment period, withdrew during the treatment period, or withdrew during the washout period; two patients included in the counts for ‘withdrawn during a treatment period’ and not included in the counts and percentages for ‘withdrawn during a washout period’ actually withdrew during a washout period. BID, twice daily; QD, once daily; UMEC, umeclidinium bromide.