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Table 5 Genotypic-phenotypic features in atopic and non-atopic patients with mild, moderate and severe asthma

From: The effect of CD14 and TLR4 gene polimorphisms on asthma phenotypes in adult Turkish asthma patients: a genetic study

 

Atopic asthmatics

p

Non-atopic asthmatics

p

(Standart deviation)

 

(Standart deviation)

 
 

1

2

3

 

1

2

3

 
 

(n = 15)

(n = 66)

(n = 15)

 

(n = 4)

(n = 12)

(n = 19)

 

FEV1 (%)

88

72

51

<0.001

89

69

52

0.03

(6.7)

(4.2)

(6.2)

 

(4.4)

(5.1)

(4.9)

 

Eosinophil (%)

3.25

4.02

3.61

0.73

1.50

1.93

2.43

0.46

(3)

(3.35)

(2.5)

 

(0.6)

(1.2)

(1.4)

 

Total IgE (kU/L)

170

240

199

0.63

63

40

43

0.49

(156)

(255)

(244)

 

(47)

(33)

(38)

 

Log IgE median

2

2.1

2

0.75

1.7

1.4

1.5

0.49

 

(0.5)

(0.5)

(0.6)

 

(0.5)

(0.5)

(0.4)

 

CD14-159

        

 CC

1

14

5

0.14

1

1

4

0.70

 CT

5

31

7

 

2

7

10

 

 TT (T Allele)

9

21

3

 

1

4

5

 

 CC + CT (C Allele)

6

45

12

0.049

3

8

14

0.82

TLR4 299

        

 AA

14

60

14

0.92

4

11

19

0.41

 GA

1

6

1

 

-

1

-

 

TLR4 399

        

 CC

14

58

14

0.70

4

11

19

0.41

 CT

1

8

1

 

-

1

-

 
  1. 1: Mild asthma; 2: Moderate asthma; 3: Severe asthma. FEV1: Forced expiratory volume 1. Log IgE: Logarithm IgE.
  2. Significant p value is shown with black boldface.