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Table 1 Characteristics of the study subjects

From: Predictors of expiratory flow limitation measured by forced oscillation technique in COPD

 

Patients with COPD n = 74

High EFL index group n = 37

Low EFL index group n = 37

Controls n = 39

Age (years)

73 (54 – 86)

73 (62 – 84)*

73 (54 – 86)*

35 (24 – 69)

Gender (male/female)

71/3

35/2*

36/1*

19/20

Body mass index (kg/m2)

21.1 (15.2 – 32.3)

21.6 (15.6 – 32.3)

20.8 (15.2 – 27.7)

22.0 (16.9 – 30.8)

Current/ex/never smoker

9/65/0

4/33/0*

5/32/0*

4/9/26

Pack years

53.1 (5.0 – 150.0)

62.0 (5.0 – 132.0)*

51.3 (7.5 – 150.0)*

0.0 (0.0 – 33.0)

mMRC scale

1 (0 – 4)

2 (0 – 4)†

1 (0 – 4)

NA

CAT score

12.5 (0 – 32)

14 (3 – 32)

11 (0 – 30)

NA

Emphysema score

10 (0 – 23)

12 (0 – 23)

10 (0 – 21)

NA

GOLD I/II/III/IV

9/31/20/14

1/9/15/12†

8/22/5/2

NA

LAMA

26

11

15

NA

LABA

4

2

2

NA

LAMA + LABA

26

15

11

NA

LAMA + ICS/LABA

13

7

6

NA

Sustained-release theophylline

24

18†

6

NA

FEV1 (% predicted)

52.6 (17.8 – 108.0)

36.8 (17.8 – 108.0)†*

67.5 (20.0 – 93.8)*

100.0 (76.9 – 118.5)

FVC (% predicted)

81.4 (34.9 – 144.0)

75.6 (34.9 – 144.0)†*

91.4 (42.5 – 114.9)*

102.7 (82.5 – 123.1)

FEV1/FVC (%)

50.1 (28.7 – 69.9)

42.0 (28.7 – 66.8)†*

59.2 (30.4 – 69.9)*

84.2 (73.5 – 97.7)

IC (% predicted)

83.0 (38.5 – 124.8)

78.4 (38.5 – 121.6)†*

86.7 (53.6 – 124.8)

94.2 (62.5 – 146.4)

FEF 25-75% (% predicted)

18.6 (5.7 – 57.4)

10.1 (5.7 – 37.7)†*

28.5 (6.3 – 57.4)*

83.4 (45.8 – 114.3)

FRC (% predicted)

100.1 (56.9 – 165.5)

111.9 (65.4 – 165.5)†

85.8 (56.9 – 123.4)*

107.9 (66.2 – 138.4)

RV (% predicted)

149.0 (34.4 – 332.0)

182.4 (94.0 – 332.0)†*

133.1 (34.4 – 213.6)*

94.4 (65.1 – 239.6)

TLC (% predicted)

109.0 (75.9 – 152.2)

116.9 (76.5 – 152.2)†

101.5 (75.9 – 133.2)

107.9 (84.2 – 147.5)

RV/TLC (% predicted)

118.2 (35.7 – 180.7)

135.5 (71.8 – 180.7)†*

106.2 (35.7 – 162.9)

112.3 (68.7 – 168.5)

  1. Values are shown as a median (range) or numbers.
  2. Abbreviations: CAT COPD assessment test, EFL expiratory flow limitation, FEF 25-75% forced expiratory flow between 25% and 75% of FVC, FEV1 forced expiratory volume in 1 second, FRC functional residual capacity, FVC forced vital capacity, GOLD Global Initiative for Chronic Obstructive Lung Disease, IC inspiratory capacity, ICS inhaled corticosteroids, LABA long-acting β2-agonists, LAMA long-acting antimuscarinic agents, mMRC modified Medical Research Council, NA not applicable, RV residual volume, TLC total lung capacity.
  3. *p <0.05 versus controls, †p <0.05 versus low EFL index group.
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BMC Pulmonary Medicine

ISSN: 1471-2466

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