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Table 1 Biomarker patterns in BALF

From: Pharmacologic inhibition of S-nitrosoglutathione reductase protects against experimental asthma in BALB/c mice through attenuation of both bronchoconstriction and inflammation

Biomarker1 Non-sensitized OVA-sensitized N6022 0.1 mg/kg N6022 1 mg/kg
Eotaxin 2.0 ± 0.5* 35.7 ± 13.8 3.8 ± 0.7* 7.3 ± 1.8*
Fibrinogen 2798.0 ± 697.7 52020.0 ± 15925.8 3820.0 ± 453.2* 7120.0 ± 1338.4*
FGF-9 606.0 ± 64.0* 1022.0 ± 160.7 566.0 ± 39.2* 598.0 ± 40.8*
FGF-2 1830.0 ± 311.3* 4540.0 ± 429.7 2560.0 ± 485.4* 3000.0 ± 320.9*
KC/GROα ND2 29.8 ± 8.7 ND ND
IFNγ 2.3 ± 0.3* 10.3 ± 2.5 3.6 ± 0.8* 5.3 ± 0.6*
IP-10 2.5 ± 0.2* 15.5 ± 5.3 3.5 ± 0.4* 3.7 ± 0.4*
IL-1β ND 536.0 ± 36.0 ND ND
IL-4 8.4 ± 1.1* 42.8 ± 10.2 10.7 ± 1.0* 14.4 ± 1.6*
IL-5 ND 488.2 ± 179.7 ND ND
IL-6 ND 76.3 ± 32.7 ND ND
IL-7 27.8 ± 2.9* 74.6 ± 14.9 22.2 ± 3.0* 33.4 ± 1.7*
IL-10 65.6 ± 3.1* 110.6 ± 16.7 60.4 ± 8.2* 87.2 ± 8.3
IL-11 20.6 ± 0.7* 38.0 ± 9.1 19.0 ± 1.1* 20.2 ± 1.0*
IL-12p70 22.2 ± 3.5* 48.4 ± 8.2 23.6 ± 3.9* 32.4 ± 5.2
IL-17A 1.1 ± 0.1* 2.4 ± 0.4 1.6 ± 0.3 1.7 ± 0.2
IL-18 642.2 ± 72.0* 7180.0 ± 1438.2 1252.0 ± 221.1* 1152.2 ± 220.1*
Lymphotactin 7.1 ± 1.1* 21.4 ± 4.2 10.7 ± 1.2* 11.0 ± 1.3*
MDC 11.6 ± 1.9* 203.0 ± 68.5 24.2 ± 5.6* 22.2 ± 4.2*
MIP-1α ND 1798.0 ± 321.1 404.0 ± 72.8* 378.0 ± 55.2*
MIP-1β 31.8 ± 2.7* 838.4 ± 158.9 36.6 ± 3.2* 49.4 ± 3.6*
MIP-1γ 109.2 ± 27.6* 2024.0 ± 625.3 250.0 ± 46.3* 182.0 ± 32.9*
MIP-2 4.3 ± 0.8* 39.8 ± 6.5 5.2 ± 0.8* 7.4 ± 1.5*
MIP-3β 55.2 ± 12.2* 315.4 ± 69.1 113.4 ± 21.7* 129.2 ± 27.3*
MMP-9 180.6 ± 38.7* 27180.0 ± 11205.5 230.0 ± 24.3* 308.0 ± 60.8*
MCP-1 ND 87.2 ± 31.3 ND ND
MCP-3 1.6 ± 0.1* 142.0 ± 36.0 3.0 ± 0.6* 2.8 ± 0.5*
MCP-5 0.4 ± 0.1* 3.6 ± 0.9 0.7 ± 0.2* 0.7 ± 0.2*
MPO 1550.0 ± 284.6* 435600.0 ± 104051.2 4500.0 ± 545.0* 7580.0 ± 1211.0*
SAP 43.4 ± 1.7* 144.8 ± 35.6 49.0 ± 4.6* 52.0 ± 2.3*
SCF 77.2 ± 6.6* 288.0 ± 67.9 80.0 ± 9.4* 97.0 ± 9.3*
RANTES 0.0019 ± 0.0004* 0.0077 ± 0.0025 0.0025 ± 0.0004* 0.0027 ± 0.0003*
TIMP-1 23.6 ± 2.8* 5476.0 ± 2394.1 34.0 ± 5.2* 30.2 ± 2.4*
TNFα 11.5 ± 2.9* 42.0 ± 10.0 11.1 ± 1.3* 14.7 ± 2.1*
sVCAM-1 522.0 ± 99.1* 4328.0 ± 1669.3 898.0 ± 127.8* 736.0 ± 106.1*
  1. BALF was collected from mice by lavaging both lungs with one mL PBS four times. Biomarker levels were determined using a multi-analyte profile of biomarker patterns. Values are the means ± SEM (N = 5).
  2. *p < 0.05 vs. OVA-sensitized, One-way ANOVA, Dunnett’s.
  3. 1Reported in pg/mL except for fibrinogen and SAP which are reported in ng/mL. 2ND = not detectable.