Biomarker1 | Non-sensitized | OVA-sensitized | N6022 0.1 mg/kg | N6022 1 mg/kg |
---|---|---|---|---|
Eotaxin | 2.0 ± 0.5* | 35.7 ± 13.8 | 3.8 ± 0.7* | 7.3 ± 1.8* |
Fibrinogen | 2798.0 ± 697.7 | 52020.0 ± 15925.8 | 3820.0 ± 453.2* | 7120.0 ± 1338.4* |
FGF-9 | 606.0 ± 64.0* | 1022.0 ± 160.7 | 566.0 ± 39.2* | 598.0 ± 40.8* |
FGF-2 | 1830.0 ± 311.3* | 4540.0 ± 429.7 | 2560.0 ± 485.4* | 3000.0 ± 320.9* |
KC/GROα | ND2 | 29.8 ± 8.7 | ND | ND |
IFNγ | 2.3 ± 0.3* | 10.3 ± 2.5 | 3.6 ± 0.8* | 5.3 ± 0.6* |
IP-10 | 2.5 ± 0.2* | 15.5 ± 5.3 | 3.5 ± 0.4* | 3.7 ± 0.4* |
IL-1β | ND | 536.0 ± 36.0 | ND | ND |
IL-4 | 8.4 ± 1.1* | 42.8 ± 10.2 | 10.7 ± 1.0* | 14.4 ± 1.6* |
IL-5 | ND | 488.2 ± 179.7 | ND | ND |
IL-6 | ND | 76.3 ± 32.7 | ND | ND |
IL-7 | 27.8 ± 2.9* | 74.6 ± 14.9 | 22.2 ± 3.0* | 33.4 ± 1.7* |
IL-10 | 65.6 ± 3.1* | 110.6 ± 16.7 | 60.4 ± 8.2* | 87.2 ± 8.3 |
IL-11 | 20.6 ± 0.7* | 38.0 ± 9.1 | 19.0 ± 1.1* | 20.2 ± 1.0* |
IL-12p70 | 22.2 ± 3.5* | 48.4 ± 8.2 | 23.6 ± 3.9* | 32.4 ± 5.2 |
IL-17A | 1.1 ± 0.1* | 2.4 ± 0.4 | 1.6 ± 0.3 | 1.7 ± 0.2 |
IL-18 | 642.2 ± 72.0* | 7180.0 ± 1438.2 | 1252.0 ± 221.1* | 1152.2 ± 220.1* |
Lymphotactin | 7.1 ± 1.1* | 21.4 ± 4.2 | 10.7 ± 1.2* | 11.0 ± 1.3* |
MDC | 11.6 ± 1.9* | 203.0 ± 68.5 | 24.2 ± 5.6* | 22.2 ± 4.2* |
MIP-1α | ND | 1798.0 ± 321.1 | 404.0 ± 72.8* | 378.0 ± 55.2* |
MIP-1β | 31.8 ± 2.7* | 838.4 ± 158.9 | 36.6 ± 3.2* | 49.4 ± 3.6* |
MIP-1γ | 109.2 ± 27.6* | 2024.0 ± 625.3 | 250.0 ± 46.3* | 182.0 ± 32.9* |
MIP-2 | 4.3 ± 0.8* | 39.8 ± 6.5 | 5.2 ± 0.8* | 7.4 ± 1.5* |
MIP-3β | 55.2 ± 12.2* | 315.4 ± 69.1 | 113.4 ± 21.7* | 129.2 ± 27.3* |
MMP-9 | 180.6 ± 38.7* | 27180.0 ± 11205.5 | 230.0 ± 24.3* | 308.0 ± 60.8* |
MCP-1 | ND | 87.2 ± 31.3 | ND | ND |
MCP-3 | 1.6 ± 0.1* | 142.0 ± 36.0 | 3.0 ± 0.6* | 2.8 ± 0.5* |
MCP-5 | 0.4 ± 0.1* | 3.6 ± 0.9 | 0.7 ± 0.2* | 0.7 ± 0.2* |
MPO | 1550.0 ± 284.6* | 435600.0 ± 104051.2 | 4500.0 ± 545.0* | 7580.0 ± 1211.0* |
SAP | 43.4 ± 1.7* | 144.8 ± 35.6 | 49.0 ± 4.6* | 52.0 ± 2.3* |
SCF | 77.2 ± 6.6* | 288.0 ± 67.9 | 80.0 ± 9.4* | 97.0 ± 9.3* |
RANTES | 0.0019 ± 0.0004* | 0.0077 ± 0.0025 | 0.0025 ± 0.0004* | 0.0027 ± 0.0003* |
TIMP-1 | 23.6 ± 2.8* | 5476.0 ± 2394.1 | 34.0 ± 5.2* | 30.2 ± 2.4* |
TNFα | 11.5 ± 2.9* | 42.0 ± 10.0 | 11.1 ± 1.3* | 14.7 ± 2.1* |
sVCAM-1 | 522.0 ± 99.1* | 4328.0 ± 1669.3 | 898.0 ± 127.8* | 736.0 ± 106.1* |