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Table 1 Biomarker patterns in BALF

From: Pharmacologic inhibition of S-nitrosoglutathione reductase protects against experimental asthma in BALB/c mice through attenuation of both bronchoconstriction and inflammation

Biomarker1

Non-sensitized

OVA-sensitized

N6022 0.1 mg/kg

N6022 1 mg/kg

Eotaxin

2.0 ± 0.5*

35.7 ± 13.8

3.8 ± 0.7*

7.3 ± 1.8*

Fibrinogen

2798.0 ± 697.7

52020.0 ± 15925.8

3820.0 ± 453.2*

7120.0 ± 1338.4*

FGF-9

606.0 ± 64.0*

1022.0 ± 160.7

566.0 ± 39.2*

598.0 ± 40.8*

FGF-2

1830.0 ± 311.3*

4540.0 ± 429.7

2560.0 ± 485.4*

3000.0 ± 320.9*

KC/GROα

ND2

29.8 ± 8.7

ND

ND

IFNγ

2.3 ± 0.3*

10.3 ± 2.5

3.6 ± 0.8*

5.3 ± 0.6*

IP-10

2.5 ± 0.2*

15.5 ± 5.3

3.5 ± 0.4*

3.7 ± 0.4*

IL-1β

ND

536.0 ± 36.0

ND

ND

IL-4

8.4 ± 1.1*

42.8 ± 10.2

10.7 ± 1.0*

14.4 ± 1.6*

IL-5

ND

488.2 ± 179.7

ND

ND

IL-6

ND

76.3 ± 32.7

ND

ND

IL-7

27.8 ± 2.9*

74.6 ± 14.9

22.2 ± 3.0*

33.4 ± 1.7*

IL-10

65.6 ± 3.1*

110.6 ± 16.7

60.4 ± 8.2*

87.2 ± 8.3

IL-11

20.6 ± 0.7*

38.0 ± 9.1

19.0 ± 1.1*

20.2 ± 1.0*

IL-12p70

22.2 ± 3.5*

48.4 ± 8.2

23.6 ± 3.9*

32.4 ± 5.2

IL-17A

1.1 ± 0.1*

2.4 ± 0.4

1.6 ± 0.3

1.7 ± 0.2

IL-18

642.2 ± 72.0*

7180.0 ± 1438.2

1252.0 ± 221.1*

1152.2 ± 220.1*

Lymphotactin

7.1 ± 1.1*

21.4 ± 4.2

10.7 ± 1.2*

11.0 ± 1.3*

MDC

11.6 ± 1.9*

203.0 ± 68.5

24.2 ± 5.6*

22.2 ± 4.2*

MIP-1α

ND

1798.0 ± 321.1

404.0 ± 72.8*

378.0 ± 55.2*

MIP-1β

31.8 ± 2.7*

838.4 ± 158.9

36.6 ± 3.2*

49.4 ± 3.6*

MIP-1γ

109.2 ± 27.6*

2024.0 ± 625.3

250.0 ± 46.3*

182.0 ± 32.9*

MIP-2

4.3 ± 0.8*

39.8 ± 6.5

5.2 ± 0.8*

7.4 ± 1.5*

MIP-3β

55.2 ± 12.2*

315.4 ± 69.1

113.4 ± 21.7*

129.2 ± 27.3*

MMP-9

180.6 ± 38.7*

27180.0 ± 11205.5

230.0 ± 24.3*

308.0 ± 60.8*

MCP-1

ND

87.2 ± 31.3

ND

ND

MCP-3

1.6 ± 0.1*

142.0 ± 36.0

3.0 ± 0.6*

2.8 ± 0.5*

MCP-5

0.4 ± 0.1*

3.6 ± 0.9

0.7 ± 0.2*

0.7 ± 0.2*

MPO

1550.0 ± 284.6*

435600.0 ± 104051.2

4500.0 ± 545.0*

7580.0 ± 1211.0*

SAP

43.4 ± 1.7*

144.8 ± 35.6

49.0 ± 4.6*

52.0 ± 2.3*

SCF

77.2 ± 6.6*

288.0 ± 67.9

80.0 ± 9.4*

97.0 ± 9.3*

RANTES

0.0019 ± 0.0004*

0.0077 ± 0.0025

0.0025 ± 0.0004*

0.0027 ± 0.0003*

TIMP-1

23.6 ± 2.8*

5476.0 ± 2394.1

34.0 ± 5.2*

30.2 ± 2.4*

TNFα

11.5 ± 2.9*

42.0 ± 10.0

11.1 ± 1.3*

14.7 ± 2.1*

sVCAM-1

522.0 ± 99.1*

4328.0 ± 1669.3

898.0 ± 127.8*

736.0 ± 106.1*

  1. BALF was collected from mice by lavaging both lungs with one mL PBS four times. Biomarker levels were determined using a multi-analyte profile of biomarker patterns. Values are the means ± SEM (N = 5).
  2. *p < 0.05 vs. OVA-sensitized, One-way ANOVA, Dunnett’s.
  3. 1Reported in pg/mL except for fibrinogen and SAP which are reported in ng/mL. 2ND = not detectable.