Secondary pulmonary alveolar proteinosis complicating myelodysplastic syndrome results in worsening of prognosis: a retrospective cohort study in Japan

Table 2 Clinical status at death (n = 17)

		WPSS at diagnosis	WHO criteria at diagnosis of MDS	AML progression	Progression of PAP	Pneumonia
	No.			6 (35.3%)	11 (64.7%)	11 (64.7%)
Mild MDS	1	Very low + low	RA			●
	2		RA		●
	3		RA	●		●
	4		RA		●	●
	5		RA	●
	6		RA		●
	7		RA		●
Severe MDS	8	Intermediate	RA			●
	9		RA		●	●
	10		RA		●	●
	11		RA	●	●	●
	12		RA	●		●
	13		RCMD		●
	14	High + very high	RA		●	●
	15		RCMD	●	●
	16		RAEB-1		●	●
	17		RAEB-2	●		●

AML, acute myeloid leukemia; MDS, myelodysplastic syndrome; PAP, pulmonary alveolar proteinosis; RA, refractory anemia; RAEB, refractory anemia with blasts; RCMD, refractory anemia with multilineage dysplasia; WHO, World Health Organization; WPSS, WHO classification-based prognostic scoring system.