Table 3 Change from baseline and treatment differences (glycopyrronium vs tiotropium) in IC at all time points evaluated on Day 1 and Week 12 (PPS)
LSM (95% CI) treatment difference glycopyrronium versus tiotropium | Mean (SD) change from baseline (L) | ||
|---|---|---|---|
Time point | Glycopyrronium (N = 300) | Tiotropium (N = 293) | |
Day 1 | |||
25 min | 0.078 (0.033,0.123)* | 0.242 (0.252) | 0.166 (0.236) |
2 h | 0.098 (0.045,0.152)* | 0.298 (0.304) | 0.197 (0.268) |
4 h | 0.035 (−0.021,0.090) | 0.234 (0.284) | 0.198 (0.307) |
24 h | 0.004 (−0.050,0.057) | 0.117 (0.293) | 0.111 (0.281) |
Week 12 | |||
−20 min | −0.029 (−0.097,0.038) | 0.087 (0.369) | 0.099 (0.355) |
25 min | 0.012 (−0.054,0.079) | 0.211 (0.365) | 0.187 (0.345) |
2 h | 0.055 (−0.014,0.124) | 0.266 (0.368) | 0.207 (0.385) |
4 h | 0.037 (−0.033,0.107) | 0.233 (0.371) | 0.186 (0.367) |
24 h | −0.034 (−0.101,0.033) | 0.126 (0.357) | 0.148 (0.360) |