Serum heat shock protein 47 levels are elevated in acute interstitial pneumonia

BMC Pulmonary Medicine

Table 2 Serum concentrations of HSP47, KL-6, SP-A, SP-D, and LDH

	Healthy volunteer (N = 19)		[n]	COP (N = 12)		[n]	NSIP (N = 16)		[n]	IPF (N = 19)		[n]	AIP (N = 9)		[n]	p value
HSP47 (pg/mL)	565.8	(332.1-879.8)	[19]	239.1	(16.6-476.6)	[12]	290.7	(24.8-603.0)	[16]	330.9	(105.1-487.6)	[19]	1530.2*	(1075.1-3919.9)	[9]	<0.001
KL-6 (U/mL)	193.0	(144-322)	[19]	427.5	(172-1310)	[10]	1568.5^¶	(192-4745)	[14]	1460^¶	(444-4340)	[15]	332.5	(201-2200)	[8]	<0.001
SP-A (ng/mL)	22.7	(12.1-60.8)	[19]	52.8	(20.6-129)	[8]	48.9	(20.3-127)	[12]	103^§	(62.4-355)	[15]	138^£	(43.8-148)	[6]	<0.001
SP-D (ng/mL)	17.3	(17.3-58.6)	[19]	105.7	(27.8-247)	[8]	477.0	(17.2-942)	[13]	316.0	(93.1-721)	[14]	417^#	(72.1-4510)	[8]	<0.001
LDH (IU/L)	124.5	(20-246)	[19]	164.0	(132-236)	[12]	212.5^#	(135-738)	[14]	233^#	(113-416)	[15]	380*	(231-736)	[9]	<0.001

Data presented as median (range).
N = number of patients; n = number of patients examined; COP = cryptogenic organizing pneumonia; NSIP = nonspecific interstitial pneumonia; IPF = idiopathic pulmonary fibrosis; AIP = acute interstitial pneumonia; HSP47 = heat shock protein 47; KL-6 = Krebs von den Lungen-6; SP-A = surfactant protein-A; SP-D = surfactant protein-D; LDH = lactate dehydrogenase.
*P < 0.01 compared with COP, NSIP, IPF, and healthy volunteers.
^¶P < 0.01 compared with healthy volunteers; P < 0.05 compared with COP.
^§P < 0.01 compared with NSIP and healthy volunteers; P < 0.05 compared with COP.
^£P < 0.01 compared with healthy volunteers.
^#P < 0.05 compared with healthy volunteers.

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