Figure 1

TCR Vβ expansions in CD4 ⁺ -BAL (A) and PBMC (B). Each circle indicates a sample from one patient. Nine of the patients had one or more expansions (filled circles) of CD4⁺ T cells expressing a particular Vβ gene segment in the BAL fluid (A). Vβ5.1, Vβ12 and Vβ16 were expressed as T cell expansions in two patients each, Vβ22 in three patients; Vβ1, Vβ2, Vβ13.1, Vβ13.2, Vβ17, Vβ18 and Vβ23 were expressed as expansions in one patient each. In PBMC (B) 6 patients had T cell expansions expressing a particular Vβ gene segment. Vβ2, Vβ7.2 and Vβ13.1 were expressed as expansions in one patient each; segments Vβ8, Vβ12 and Vβ20 were expressed as expansions in two patients each. (Definition of T cell expansion was > mean plus two* SD of a cohort of healthy controls subjects).