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Table 1 Clinical summary of included studies examining the diagnostic accuracy of pleural cholesterol level

From: Can cholesterol be used to distinguish pleural exudates from transudates? evidence from a bivariate meta-analysis

Study (ref no.) Year Country No. patients Standard Method Cut-off (mg/l) TP FP FN TN QUADAS score Misclassified*
Exu Trans
Hamm H [16] 1987 Germany 31 31 Clinical criteria ECM 60 28 3 3 28 8 9/30
Valdés L [17] 1991 Spain 188 65 Clinical criteria ECM 55 171 0 17 65 9 14/65
Romero S [18] 1993 Spain 253 44 Clinical criteria ECM 60 206 4 47 40 8 10/44
Burgess LJ [19] 1995 South Africa 270 123 Clinical criteria ESM 50 184 11 86 112 7 19/112
Costa M [20] 1995 Chile 131 49 Clinical criteria ECM 45 118 0 13 49 9 9/49
Gil Suay V [21] 1995 Spain 156 48 Clinical criteria ECM 54 149 4 7 44 8 17/48
Garcia-Pachon E [22] 1996 Spain 118 35 Clinical criteria NA 50 107 1 11 34 10 9/35
Kalayci AG [23] 1996 Turkey 40 20 Clinical criteria ECM 40 36 1 4 19 9 NA
Metintaş M [24] 1997 Turkey 72 21 Clinical criteria ECM 60 54 3 18 18 10 4/21
Gázquez I [25] 1998 Spain 155 38 Clinical criteria ECM 50 130 6 25 32 7 11/38
Romero S [26] 2000 Spain 182 61 Clinical criteria ECM 60 155 5 27 56 9 9/61
Yilmaz A [27] 2000 Turkey 150 105 Clinical criteria ECM 60 143 4 7 101 8 13/105
Porcel JM [28] 2001 Spain 139 32 Clinical criteria ECM 60 111 1 28 31 9 8/32
Alexandrakis MG [29] 2002 Greece 82 24 Light's criteria NA 65 76 0 6 24 10 NA
Guleria R [30] 2003 India 50 25 Clinical criteria NA 60 44 0 6 25 9 5/25
Leers MP [31] 2007 Netherlands 300 108 Clinical criteria ECM 60 227 2 73 106 11 29/108
Razi E [32] 2008 Iran 70 49 Light's criteria NA 38 61 10 9 39 8 NA
Hamal AB [33] 2013 Nepal 43 19 Clinical criteria ECM 45 42 0 1 19 12 NA
Patel AK [34] 2013 India 49 11 Clinical criteria NA 60 48 0 1 11 11 0/11
  1. Abbreviations: ECM, enzymatic colorimetric method; ESM, enzymatic spectrophotometric method; Exu, pleural exudate; Trans, transudate; TP, no. of true positives; FP, no. of false positives; FN, no. of false negatives; NA, not applicable; TN, no. of true negatives; QUADAS, quality assessment of diagnostic accuracy studies.
  2. *No. of transudates misclassified as exudates based on Light’s criteria (misclassifications/total).