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Table 3 Hemodynamic, IVUS and echocardiographic data at rest and during stress maneuver of both PAH groups

From: Impairment of pulmonary vascular reserve and right ventricular systolic reserve in pulmonary arterial hypertension

 

PAH 1

PAH 2

 

ΔmPAP > 5 (n = 9)

ΔmPAP ≤ 5 (n = 9)

 

Rest

Stress

Rest

Stress

CO, L/min

3.8 ± 0.5

5.0 ± 0.7§

4.2 ± 0.4

6.1 ± 0.5§

HR, bpm

76 ± 4

104 ± 5.3§

75 ± 4.6

105 ± 5.1§

SV, mL

54 ± 9

50 ± 9§

56 ± 6

60 ± 5

mPAP, mm Hg

54 ± 6.7

71 ± 7.2§

50 ± 4.7

51 ± 4.6*

pPAP, mm Hg

52 ± 6.7

76 ± 9.2§

45 ± 7.6

53 ± 6.4*

PCWP, mm Hg

10.6 ± 1.1

9.4 ± 1.1

10.3 ± 1.9

6.0 ± 1.3

RAP, mm Hg

7.9 ± 1.0

8.4 ± 0.8

6.9 ± 1.6

7.1 ± 1.2

PVR, Wood units

13.7 ± 2.8

14.9 ± 3.1

10.3 ± 1.7

7.9 ± 1.3*§

PC, mL/mm Hg

1.38 ± 0.4

0.9 ± 0.4§

1.6 ± 0.38

1.3 ± 0.2

TPR, Wood units

16.6 ± 3.1

17.0 ± 3.1

13.1 ± 2.2

9.2 ± 1.8*§

IVUSp, %

29 ± 5.7

26 ± 6.6

38 ± 7.8

28 ± 4.8

EM, mm Hg

211 ± 32

362 ± 55§

158 ± 39

187 ± 23*

TAPSE, mm

16.4 ± 1.9

20.8 ± 1.9§

20.3 ± 1.4

19.6 ± 1.1

Sm, cm s-1

12.1 ± 0.64

15.3 ± 1.2§

12.8 ± 1.0

13.3 ± 1.0

IVA, m s-2

3.3 ± 0.35

5.9 ± 0.7§

4.3 ± 0.5

9.9 ± 1.5*§

  1. *p < 0.05 between both groups in the same condition; §p < 0.05 between both conditions in the same group.
  2. CO: cardiac output; PC: pulmonary capacitance index; EM: elastic modulus; HR: heart rate; IVA: myocardial isovolumic acceleration; IVUSp: pulmonary arterial pulsatility; PCWP: pulmonary capillary wedge pressure; mPAP and pPAP: mean and pulse arterial pulmonary pressures; PVR: pulmonary vascular resistance; Sm: myocardial peak systolic velocity; RAP: right atrial pressure; SV: stroke volume; TAPSE: tricuspid annular plane systolic excursion; TPR: total pulmonary resistance.