PIF | Phase 1 | Inspiration | Global ROI | Ventral ROI$/§ | Middle ROI | Dorsal ROI | |
---|---|---|---|---|---|---|---|
PEEP [mbar] | VT/weight [ml/kg] | Lung | n | Mean ± sd [ml/s] | Mean ± sd [ml/s] | Mean ± sd [ml/s] | Mean ± sd [ml/s] |
0 | 15 | healthy | 7 | 467.27 ± 56.69 | 109.87 ± 15.45 | 317.60 ± 34.38 | 298.54 ± 120.62 |
0 | 20 | healthy | 7 | 571.94 ± 100.47 | 126.10 ± 17.69 | 345.79 ± 54.36 | 327.13 ± 127.57 |
5 | 15 | healthy | 7 | 510.92 ± 102.16 | 116.04 ± 14.20 | 324.25 ± 73.59 | 334.11 ± 135.32 |
5 | 20 | healthy | 7 | 621.80 ± 85.20 | 129.70 ± 16.65 | 396.75 ± 50.78 | 348.89 ± 139.71 |
10 | 15 | healthy | 7 | 550.89 ± 82.35 | 105.82 ± 13.13 | 335.46 ± 48.16 | 339.63 ± 132.18 |
10 | 20 | healthy | 7 | 711.67 ± 104.68 | 123.85 ± 22.84 | 424.07 ± 84.16 | 402.98 ± 143.06 |
5 | 15 | healthy | 6 | 901.90 ± 92.06 | 118.94 ± 32.59 | 512.73 ± 81.67 | 283.00 ± 59.44 |
5 | 15 | LAV | 6 | 968.55 ± 64.49 | 158.94* ± 24.26 | 602.78* ± 91.51 | 335.89 ± 83.67 |
LIF | Phase 2 | Inspiration | Global ROI | Ventral ROI $ | Middle ROI | Dorsal ROI | |
PEEP [mbar] | V T /weight [ml/kg] | Lung | n | Mean ± sd [ml/s] | Mean ± sd [ml/s] | Mean ± sd [ml/s] | Mean ± sd [ml/s] |
0 | 15 | healthy | 7 | 72.04 ± 16.52 | 10.26 ± 5.27 | 36.77 ± 28.00 | 19.03 ± 4.99 |
0 | 20 | healthy | 7 | 86.66 ± 36.51 | 10.80 ± 4.08 | 43.22 ± 24.84 | 17.66 ± 4.93 |
5 | 15 | healthy | 7 | 55.58 ± 23.32 | 5.65 ± 4.35 | 18.02 ± 3.12 | 16.05 ± 4.31 |
5 | 20 | healthy | 7 | 52.11 ± 10.05 | 9.50 ± 4.76 | 27.59 ± 15.06 | 10.45 ± 5.20 |
10 | 15 | healthy | 7 | 47.17 ± 16.57 | 7.83 ± 3.67 | 23.31 ± 8.22 | 11.93 ± 9.44 |
10 | 20 | healthy | 7 | 64.37 ± 45.81 | 8.69 ± 4.00 | 32.91 ± 5.27 | 18.07 ± 15.34 |
5 | 15 | healthy | 6 | 13.58 ± 2.70 | 4.03 ± 0.52 | 18.55 ± 8.65 | 12.72 ± 5.84 |
5 | 15 | LAV | 6 | 19.09* ± 5.14 | 2.82 ± 1.83 | 10.74* ± 5.29 | 13.02 ± 3.73 |
PEF | Phase 3 | Expiration | Global ROI | Ventral ROI $/§ | Middle ROI | Dorsal ROI | |
PEEP [mbar] | V T / weight [ml/kg] | Lung | n | Meann ± msd [ml/s] | Mean ± sd [ml/s] | Mean ± sd [ml/s] | Mean ± sd [ml/s] |
0 | 15 | healthy | 7 | -587.38 ± 86.73 | -130.15 ± 21.79 | -360.79 ± 60.67 | -344.81 ± 140.78 |
0 | 20 | healthy | 7 | -687.01 ± 138.84 | -141.14 ± 24.29 | -419.64 ± 68.85 | -360.89 ± 135.22 |
5 | 15 | healthy | 7 | -609.64 ± 164.78 | -122.24 ± 16.87 | -359.02 ± 71.82 | -351.49 ± 156.67 |
5 | 20 | healthy | 7 | -675.96 ± 142.03 | -119.51 ± 20.03 | -397.41 ± 67.45 | -413.33 ± 170.68 |
10 | 15 | healthy | 7 | -581.72 ± 119.23 | -107.19 ± 13.15 | -356.31 ± 53.46 | -353.22 ± 127.59 |
10 | 20 | healthy | 7 | -685.25 ± 114.72 | -108.40 ± 13.30 | -395.27 ± 41.11 | -383.60 ± 152.15 |
5 | 15 | healthy | 6 | -666.61 ± 62.94 | -94.05 ± 12.91 | -373.52 ± 74.09 | -257.96 ± 47.51 |
5 | 15 | LAV | 6 | -734.43* ± 44.74 | -130.40* ± 26.63 | -441.15 ± 102.11 | -349.22 ± 145.95 |
LEF | Phase 4 | Expiration | Global ROI | Ventral ROI $ | Middle ROI § | Dorsal ROI | |
PEEP [mbar] | V T / weight [ml/kg] | Lung | n | Mean ± sd [ml/s] | Mean ± sd [ml/s] | Mean ± sd [ml/s] | Mean ± sd [ml/s] |
0 | 15 | healthy | 7 | -40.23 ± 25.65 | -5.74 ± 4.36 | -27.25 ± 14.37 | -7.11 ± 5.85 |
0 | 20 | healthy | 7 | -58.85 ± 30.50 | -8.73 ± 4.94 | -48.72 ± 19.19 | -16.04 ± 7.86 |
5 | 15 | healthy | 7 | -50.20 ± 17.22 | -5.41 ± 4.37 | -27.87 ± 8.07 | -3.74 ± 1.78 |
5 | 20 | healthy | 7 | -62.46 ± 37.63 | -5.46 ± 2.57 | -47.50 ± 13.66 | -16.79 ± 10.81 |
10 | 15 | healthy | 7 | -49.84 ± 37.89 | -3.77 ± 2.04 | -23.78 ± 22.54 | -9.10 ± 11.72 |
10 | 20 | healthy | 7 | -86.42 ± 27.98 | -6.67 ± 3.74 | -51.34 ± 15.72 | -15.81 ± 5.00 |
5 | 15 | healthy | 6 | -39.16 ± 23.89 | -5.71 ± 3.26 | -26.44 ± 10.16 | -8.36 ± 4.09 |
5 | 15 | LAV | 6 | -36.15 ± 27.84 | -6.29 ± 2.20 | -20.37 ± 16.26 | -2.63* ± 1.00 |