Determinants of exercise capacity in cystic fibrosis patients with mild-to-moderate lung disease

BMC Pulmonary Medicine

Table 5 Determinants of VO ₂ peak in CF patients

Variable	All patients (n = 102)	Group 1 (n = 48)	Group 2 (n = 54)
FEV₁	50 (0.84 [0.70;0.98])^a	31 (1.08 [0.70;1.45])^a	18 (0.67 [0.46;0.88])^a
BR	12 (−0.62 [−0.82;-0.42])^a	6 (−0.36 [−0.68;-0.04])^b	35 (−0.85 [−1.10;-0.59])^a
V_E/VCO₂ peak	5 (−1.13 [−1.56;-0.69])^a	15 (−0.95 [−1.41;-0.48])^c	6 (−1.52 [−2.22;-0.82])^a

Results are expressed as the partial r-square (r²), i.e. the percentage of VO₂ alteration explained by the variable. Coefficient and 95% confidence intervals are shown between parentheses. FEV_1, V_E/VCO₂ peak, and BR were independent predictors explaining 67% of exercise capacity (r² = 0.67). In group 1, 31% of the VO₂ peak was explained by FEV₁, whereas, in group 2, BR was the major determinant explaining 35% of the VO₂ peak.
Results are derived from multivariable analysis.
^aAdjusted p value < .0001; ^bp = .027; ^cp = .0002.

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