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Table 5 Determinants of VO 2 peak in CF patients

From: Determinants of exercise capacity in cystic fibrosis patients with mild-to-moderate lung disease

Variable All patients (n = 102) Group 1 (n = 48) Group 2 (n = 54)
FEV1 50 (0.84 [0.70;0.98])a 31 (1.08 [0.70;1.45])a 18 (0.67 [0.46;0.88])a
BR 12 (−0.62 [−0.82;-0.42])a 6 (−0.36 [−0.68;-0.04])b 35 (−0.85 [−1.10;-0.59])a
VE/VCO2 peak 5 (−1.13 [−1.56;-0.69])a 15 (−0.95 [−1.41;-0.48])c 6 (−1.52 [−2.22;-0.82])a
  1. Results are expressed as the partial r-square (r2), i.e. the percentage of VO2 alteration explained by the variable. Coefficient and 95% confidence intervals are shown between parentheses. FEV1, VE/VCO2 peak, and BR were independent predictors explaining 67% of exercise capacity (r2 = 0.67). In group 1, 31% of the VO2 peak was explained by FEV1, whereas, in group 2, BR was the major determinant explaining 35% of the VO2 peak.
  2. Results are derived from multivariable analysis.
  3. aAdjusted p value < .0001; bp = .027; cp = .0002.