Figure 5

Chronic cigarette smoke model. A. C57BL/6 and NZW mice were exposed to air (no-smoke group) or for 24 weeks in the chronic study (n = 6). B. Black and white conversion of lung photomicrographs of non-smoke and smoke group mice at 24 weeks. C- D. Air-space dilatation and destruction were evaluated by Lm and DI respectively. Both were significantly increased following CS exposure in C57BL/6 but not NZW mice. *p < 0.05 compared with corresponding non-smoke groups. †p < 0.05 compared with C57BL/6 smoke groups. n = 6 for each experimental set.